Q59487

PR
Gene name
folA (dhfR, LL1150, L162872)
Protein name
Dihydrofolate reductase
Names
Species
Lactococcus lactis subsp lactis (strain IL1403) (Streptococcus lactis)
KEGG Pathway
lla:L162872
EC number
1.5.1.3: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

116-168 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q59487

Entry ID Method Resolution Chain Position Source
AF-Q59487-F1 Predicted AlphaFoldDB

No variants for Q59487

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q59487

No associated diseases with Q59487

2 regional properties for Q59487

Type Name Position InterPro Accession
domain Dihydrofolate reductase domain 1 - 164 IPR001796
conserved_site Dihydrofolate reductase conserved site 13 - 35 IPR017925

Functions

Description
EC Number 1.5.1.3 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
dihydrofolate reductase activity Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

3 GO annotations of biological process

Name Definition
glycine biosynthetic process The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid.
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
tetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIIGIWAEDE AGLIGEADKM PWSLPAEQQH FKETTMNQVI LMGRKTFEGM NKRVLPGRIS
70 80 90 100 110 120
IILTRDETYQ SDNEKVLIMH SPKEVLDWYH KQNKDLFITG GAEILALFES ELELLYRTVV
130 140 150 160
HEKFKGDTYF PSTFDFGRFK LVSEKFHDKD ERNSYTFTIK KYEKVKQP