Q59156

PR
Gene name
polA (Athe_1441)
Protein name
DNA polymerase I
Names
Pol I
Species
Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
KEGG Pathway
ate:Athe_1441
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

32-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q59156

Entry ID Method Resolution Chain Position Source
AF-Q59156-F1 Predicted AlphaFoldDB

No variants for Q59156

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q59156

No associated diseases with Q59156

7 regional properties for Q59156

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family A, palm domain 473 - 848 IPR001098
domain 5'-3' exonuclease 1 - 261 IPR002421
domain 3'-5' exonuclease domain 298 - 457 IPR002562
conserved_site Helix-hairpin-helix motif, class 2 173 - 208 IPR008918
conserved_site DNA-directed DNA polymerase, family A, conserved site 676 - 695 IPR019760
domain DNA polymerase I-like, H3TH domain 171 - 265 IPR020045
domain 5'-3' exonuclease, alpha-helical arch, N-terminal 2 - 170 IPR020046

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

2 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLVIFDGNS ILYRAFFALP ELTTSNNIPT NAIYGFVNVI LKYLEQEKPD YVAVAFDKRG
70 80 90 100 110 120
REARKSEYEE YKANRKPMPD NLQVQIPYVR EILYAFNIPI IEFEGYEADD VIGSLVNQFK
130 140 150 160 170 180
NTGLDIVIIT GDRDTLQLLD KNVVVKIVST KFDKTVEDLY TVENVKEKYG VWANQVPDYK
190 200 210 220 230 240
ALVGDQSDNI PGVKGIGEKS AQKLLEEYSS LEEIYQNLDK IKSSIREKLE AGKDMAFLSK
250 260 270 280 290 300
RLATIVCDLP LNVKLEDLRT KEWNKERLYE ILVQLEFKSI IKRLGLSEVV QFEFVQQRTD
310 320 330 340 350 360
IPDVEQKELE SISQIRSKEI PLMFVQGEKC FYLYDQESNT VFITSNKLLI EEILKSDTVK
370 380 390 400 410 420
IMYDLKNIFH QLNLEDTNNI KNCEDVMIAS YVLDSTRSSY ELETLFVSYL NTDIEAVKKD
430 440 450 460 470 480
KKIVSVVLLK RLWDELLRLI DLNSCQFLYE NIERPLIPVL YEMEKTGFKV DRDALIQYTK
490 500 510 520 530 540
EIENKILKLE TQIYQIAGEW FNINSPKQLS YILFEKLKLP VIKKTKTGYS TDAEVLEELF
550 560 570 580 590 600
DKHEIVPLIL DYRMYTKILT TYCQGLLQAI NPSSGRVHTT FIQTGTATGR LASSDPNLQN
610 620 630 640 650 660
IPVKYDEGKL IRKVFVPEGG HVLIDADYSQ IELRILAHIS EDERLISAFK NNVDIHSQTA
670 680 690 700 710 720
AEVFGVDIAD VTPEMRSQAK AVNFGIVYGI SDYGLARDIK ISRKEAAEFI NKYFERYPKV
730 740 750 760 770 780
KEYLDNTVKF ARDNGFVLTL FNRKRYIKDI KSTNRNLRGY AERIAMNSPI QGSAADIMKL
790 800 810 820 830 840
AMIKVYQKLK ENNLKSKIIL QVHDELLIEA PYEEKDIVKE IVKREMENAV ALKVPLVVEV
KEGLNWYETK