Q58EK4

PR
Gene name
parl
Protein name
Presenilins-associated rhomboid-like protein, mitochondrial
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:541485
EC number
3.4.21.105: Serine endopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-101 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58EK4

Entry ID Method Resolution Chain Position Source
AF-Q58EK4-F1 Predicted AlphaFoldDB

No variants for Q58EK4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58EK4

No associated diseases with Q58EK4

1 regional properties for Q58EK4

Type Name Position InterPro Accession
domain Peptidase S54, rhomboid domain 207 - 350 IPR022764

Functions

Description
EC Number 3.4.21.105 Serine endopeptidases
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

1 GO annotations of biological process

Name Definition
signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H300 PARL Presenilins-associated rhomboid-like protein, mitochondrial Homo sapiens (Human) PR
10 20 30 40 50 60
MAWRSCFMKW TQINSINASS LCPKSTRLNI HPQQRCGFRK TERPSESKKG VQETEAEAGG
70 80 90 100 110 120
HNRAVPPKPV PPLPPRRPHQ LFRPLVFTVG FTGCSFGAAA ILQYESVKSR VQLAIEEAKE
130 140 150 160 170 180
EKRDTLLEGH DTTYWHNWWN QLSNFQKQVI LLISAVDDFW SGLSEGQKTV TGIIALNTVV
190 200 210 220 230 240
LCCWRVPAMQ RFLVKYFTSN PASKTRCLPM VLSSFSHYSV IHMVVNMYVL WTFSSSIVSL
250 260 270 280 290 300
LGREQFLALY LSGGVISTFV SYVFKTATGR LGPSLGASGS IMTVLAAVCT KIPEAKLGIV
310 320 330 340 350 360
LLPVISFSAG NALKALVALD IAGLVLGWRF FDHAAHLGGA LFGVWYIGYG HELIWRKREP
370 380
LIKFWHELRN MSPGRPGPGG GGG