Q58DP0

PR
Gene name
BUD23
Protein name
Probable 18S rRNA (guanine-N(7))-methyltransferase
Names
Bud site selection protein 23 homolog, Williams-Beuren syndrome chromosomal region 22 protein homolog, rRNA methyltransferase and ribosome maturation factor
Species
Bos taurus (Bovine)
KEGG Pathway
bta:513878
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

180-281 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58DP0

Entry ID Method Resolution Chain Position Source
AF-Q58DP0-F1 Predicted AlphaFoldDB

No variants for Q58DP0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58DP0

No associated diseases with Q58DP0

2 regional properties for Q58DP0

Type Name Position InterPro Accession
domain 18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23, C-terminal 204 - 278 IPR022238
domain Methyltransferase domain 25 57 - 130 IPR041698

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Nucleus, nucleoplasm
  • Cytoplasm, perinuclear region
  • Cytoplasm
  • Localized diffusely throughout the nucleus and the cytoplasm
  • Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes
  • Localization is not affected by glucocorticoid treatment
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

2 GO annotations of molecular function

Name Definition
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
rRNA (guanine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine.

3 GO annotations of biological process

Name Definition
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
positive regulation of rRNA processing Any process that activates or increases the frequency, rate or extent of rRNA processing.
rRNA (guanine-N7)-methylation The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O43709 BUD23 Probable 18S rRNA (guanine-N(7))-methyltransferase Homo sapiens (Human) PR
10 20 30 40 50 60
MAFRGRRPEL RGPPELYYDK NEARKYVRNS RMIDVQIKMT GRALELLCVP EDKPCYVLDI
70 80 90 100 110 120
GCGTGLSGDY LSDEGHYWVG IDISPAMLDE ALDRETQGDV ILGDMGQGIP FKPGTFDACI
130 140 150 160 170 180
SISAVQWLCN ANKKSDIPAK RLYCFFSSLY SVLVRGGRAV LQLYPENSEQ LELITTQATR
190 200 210 220 230 240
AGFTGGVVVD YPNSAKAKKF YLCLFSGPST SLPEGLSEDT EEEKPAESTF TADRIPYRIA
250 260 270 280
RRGVVRKSRE WVLEKKARRR RQGKEVCPDT QYTGRKRKPR F