Q58DA1

PR
Gene name
SPEF1
Protein name
Sperm flagellar protein 1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:512410
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

86-159 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58DA1

Entry ID Method Resolution Chain Position Source
AF-Q58DA1-F1 Predicted AlphaFoldDB

53 variants for Q58DA1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs432949309 4 S>G No EVA
rs456316374 5 V>G No EVA
rs475943795 6 D>G No EVA
rs444510210 8 E>G No EVA
rs461138070 13 L>P No EVA
rs474834383 17 V>G No EVA
rs440628861 28 N>S No EVA
rs466419279 85 P>A No EVA
rs721987110 88 V>M No EVA
rs451766147 89 M>T No EVA
rs436830141 115 Q>* No EVA
rs436830141 115 Q>K No EVA
rs456887697 116 R>G No EVA
rs473737575 116 R>S No EVA
rs442354936 118 R>T No EVA
rs475728524 134 T>P No EVA
rs207757298 137 M>I No EVA
rs438780000 141 L>W No EVA
rs451119417 148 E>V No EVA
rs461344508 149 G>C No EVA
rs481649087 149 G>D No EVA
rs466679796 151 P>R No EVA
rs432102339 154 Q>P No EVA
rs445587308 155 G>R No EVA
rs468977072 155 G>V No EVA
rs441762324 161 E>D No EVA
rs378258265 173 S>N No EVA
rs461723215 178 S>R No EVA
rs478630044 179 D>A No EVA
rs524476030 179 D>Y No EVA
rs464419599 182 F>L No EVA
rs477946786 188 E>D No EVA
rs449749303 190 E>* No EVA
rs469809067 192 E>Q No EVA
rs438031218 195 A>D No EVA
rs472233264 207 V>A No EVA
rs472233264 207 V>G No EVA
rs455953657 207 V>L No EVA
rs440891170 208 R>G No EVA
rs471227806 211 E>* No EVA
rs471227806 211 E>Q No EVA
rs443221537 212 H>N No EVA
rs463464758 212 H>R No EVA
rs480369779 216 L>I No EVA
rs459559368 223 D>A No EVA
rs479102934 223 D>E No EVA
rs464692684 227 R>T No EVA
rs478177009 228 L>P No EVA
rs450151695 233 R>S No EVA
rs435894654 234 K>R No EVA
rs455809115 235 Q>E No EVA
rs466403788 237 R>G No EVA
rs466403788 237 R>R No EVA

No associated diseases with Q58DA1

2 regional properties for Q58DA1

Type Name Position InterPro Accession
domain Calponin homology domain 7 - 112 IPR001715
domain CH-like domain in sperm protein 13 - 107 IPR010441

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell projection, cilium, flagellum
  • Cytoplasm, cytoskeleton, cilium axoneme
  • Apical cell membrane
  • Basolateral cell membrane
  • Cytoplasm, cytoskeleton, stress fiber
  • Cell projection, microvillus
  • Cell projection, lamellipodium
  • Cell projection, filopodium
  • Present in the tails of developing and epididymal sperm, internal to the fibrous sheath and around the outer dense fibers of the sperm flagellum
  • Also found at the apical tip of cilia
  • Colocalizes with TJP1 and CGN at sites of cell-cell contact in intestinal epithelial cells (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
9+2 motile cilium A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
axonemal central apparatus Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules.
axoneme The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
ciliary tip Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microvillus Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.

2 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.

10 GO annotations of biological process

Name Definition
axonemal central apparatus assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cilium movement The directed, self-propelled movement of a cilium.
filopodium assembly The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
lamellipodium assembly Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
microtubule bundle formation A process that results in a parallel arrangement of microtubules.
negative regulation of cell death Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
negative regulation of microtubule depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
regulation of cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
regulation of Wnt signaling pathway, planar cell polarity pathway Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGSVDEEAL HQLYLWVDNI PLSRPKRNLS RDFSDGVLVA EVIKFYFPKM VEMHNYVPAN
70 80 90 100 110 120
SLQQKLSNWS HLNRKVLNKL NFSVPEDVMR KIAQCAPGVV ELVLIPLRQR LEERQRRRKQ
130 140 150 160 170 180
GIGSLQELAP QDGTDYMDVG LSQKARGEGV PDPQGRGQLR EGRLPVPRPP GDSQALQSDP
190 200 210 220 230
SFILQIAEKE QELLASQETV QVLQMKVRRL EHLLQLKNVR IEDLSRRLQQ AERKQR