Q58D56

PR
Gene name
DRG2
Protein name
Developmentally-regulated GTP-binding protein 2
Names
DRG-2, Translation factor GTPase DRG2, TRAFAC GTPase DRG2
Species
Bos taurus (Bovine)
KEGG Pathway
bta:507472
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-87 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58D56

Entry ID Method Resolution Chain Position Source
AF-Q58D56-F1 Predicted AlphaFoldDB

123 variants for Q58D56

Variant ID(s) Position Change Description Diseaes Association Provenance
rs483307359 2 G>E No EVA
rs442821557 3 I>T No EVA
rs461352073 3 I>V No EVA
rs479138073 7 I>N No EVA
rs460600226 8 S>P No EVA
rs471529312 10 I>F No EVA
rs456428885 10 I>T No EVA
rs444333638 11 E>K No EVA
rs455202154 13 E>A No EVA
rs474124224 13 E>K No EVA
rs433536615 14 I>T No EVA
rs451252121 15 A>G No EVA
rs466521213 15 A>P No EVA
rs466521213 15 A>T No EVA
rs432569403 16 R>G No EVA
rs465562534 16 R>P No EVA
rs450259357 17 T>P No EVA
rs483346017 18 Q>K No EVA
rs468050859 18 Q>R No EVA
rs478980764 19 K>R No EVA
rs460643298 20 N>H No EVA
rs438885346 20 N>I No EVA
rs478342459 20 N>K No EVA
rs462773093 21 K>R No EVA
rs433179029 25 Y>D No EVA
rs469442392 34 L>F No EVA
rs41913610 36 K>* No EVA
rs457268679 36 K>R No EVA
rs468489938 38 R>W No EVA
rs479383730 39 A>V No EVA
rs464425632 43 E>V No EVA
rs445885469 44 P>T No EVA
rs482171108 46 K>T No EVA
rs463414386 55 F>I No EVA
rs441621702 59 K>E No EVA
rs440663449 65 V>E No EVA
rs440663449 65 V>G No EVA
rs459408631 65 V>L No EVA
rs451798944 72 S>T No EVA
rs463229549 77 T>P No EVA
rs137287587 83 T>P No EVA
rs133552763 84 S>P No EVA
rs137563676 85 T>P No EVA
rs473677180 106 Y>* No EVA
rs455922226 106 Y>H No EVA
rs440735869 106 Y>S No EVA
rs451713703 107 K>R No EVA
rs475711564 108 G>S No EVA
rs457231083 110 N>D No EVA
rs435644723 111 I>S No EVA
rs468254541 112 Q>* No EVA
rs468254541 112 Q>K No EVA
rs446582080 113 L>P No EVA
rs434709825 114 L>P No EVA
rs445644420 124 A>S No EVA
rs481771998 126 G>R No EVA
rs476442566 134 I>M No EVA
rs443449343 134 I>S No EVA
rs461140472 135 A>D No EVA
rs442722021 138 R>C No EVA
rs472511490 138 R>H No EVA
rs431924120 139 T>K No EVA
rs453659721 139 T>P No EVA
rs471313359 140 A>T No EVA
rs437648271 141 D>A No EVA
rs470258732 142 V>G No EVA
rs436714233 144 I>S No EVA
rs447613931 145 M>K No EVA
rs466453075 145 M>L No EVA
rs459045816 146 M>I No EVA
rs477394509 146 M>K No EVA
rs450258718 148 D>A No EVA
rs483095029 148 D>E No EVA
rs442575286 150 T>A No EVA
rs442575286 150 T>S No EVA
rs460406707 152 G>D No EVA
rs438390619 154 V>G No EVA
rs457181624 164 E>D No EVA
rs439532991 211 K>R No EVA
rs457230750 214 N>K No EVA
rs442097526 221 E>Q No EVA
rs474855896 222 D>Y No EVA
rs453059315 223 C>G No EVA
rs434712180 225 P>T No EVA
rs464424741 231 V>L No EVA
rs452150944 233 V>E No EVA
rs436742060 235 N>K No EVA
rs469885882 237 V>G No EVA
rs448129852 240 P>R No EVA
rs481160346 241 C>R No EVA
rs447026344 243 Y>* No EVA
rs468780544 243 Y>N No EVA
rs461208457 255 E>D No EVA
rs442683126 262 K>N No EVA
rs472275779 266 V>A No EVA
rs472275779 266 V>G No EVA
rs443023596 277 D>H No EVA
rs443023596 277 D>N No EVA
rs463218015 287 L>R No EVA
rs450999316 299 Q>R No EVA
rs435745671 301 P>A No EVA
rs468599922 302 D>N No EVA
rs447153784 303 F>L No EVA
rs442593453 304 T>K No EVA
rs442593453 304 T>R No EVA
rs445996404 310 R>L No EVA
rs482380287 312 G>R No EVA
rs463825383 313 A>G No EVA
rs455396386 320 H>P No EVA
rs433718337 322 I>T No EVA
rs466587080 323 H>P No EVA
rs451143107 327 A>P No EVA
rs452888232 337 G>D No EVA
rs445406981 338 T>I No EVA
rs464235305 338 T>P No EVA
rs433403067 340 T>S No EVA
rs469536228 344 P>R No EVA
rs480710979 347 V>A No EVA
rs480710979 347 V>G No EVA
rs461986442 349 L>V No EVA
rs446751191 355 H>N No EVA
rs458207629 356 E>Q No EVA
rs482119450 365 K>Y No EVA

No associated diseases with Q58D56

6 regional properties for Q58D56

Type Name Position InterPro Accession
domain TGS 288 - 363 IPR004095
domain Small GTP-binding protein domain 62 - 213 IPR005225
domain GTP binding domain 64 - 166 IPR006073
conserved_site GTP1/OBG, conserved site 115 - 128 IPR006074
domain OBG-type guanine nucleotide-binding (G) domain 63 - 288 IPR031167
domain GTP binding protein, second domain 185 - 289 IPR031662

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

4 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
metal ion binding Binding to a metal ion.
RNA binding Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name Definition
cytoplasmic translation The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P55039 DRG2 Developmentally-regulated GTP-binding protein 2 Homo sapiens (Human) PR
10 20 30 40 50 60
MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSSSS KGEGFDVMKS
70 80 90 100 110 120
GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI PGVIEYKGAN IQLLDLPGII
130 140 150 160 170 180
EGAAQGKGRG RQVIAVARTA DVVIMMLDAT KGEVQRSLLE KELESVGIRL NKHKPNIYFK
190 200 210 220 230 240
PKKGGGISFN STVTLTQCSE KLVQLILHEY KIFNAEVLFR EDCSPDEFID VIVGNRVYMP
250 260 270 280 290 300
CLYVYNKIDQ ISMEEVDRLA RKPDSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR
310 320 330 340 350 360
PDFTDAIILR KGASVEHVCH RIHRSLASQF KYALVWGTST KYSPQRVGLT HTMEHEDVIQ
IVKK