Q58889

PR
Gene name
MJ1494
Protein name
Putative 26S proteasome regulatory subunit homolog MJ1494
Names
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_1494
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58889

Entry ID Method Resolution Chain Position Source
AF-Q58889-F1 Predicted AlphaFoldDB

No variants for Q58889

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58889

No associated diseases with Q58889

3 regional properties for Q58889

Type Name Position InterPro Accession
domain AAA+ ATPase domain 153 - 288 IPR003593
domain ATPase, AAA-type, core 157 - 285 IPR003959
conserved_site ATPase, AAA-type, conserved site 258 - 277 IPR003960

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
proteasome-activating activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

1 GO annotations of biological process

Name Definition
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKIGFNPIK IKSFSKIKTY DDTLPSLKYV VLEPAGFPIR VSSENVKVST DDPILFNIYA
70 80 90 100 110 120
RDQWIGEIVK EGDYLFDNSI LPDYAFKVIS TYPKEGGMIT SETVFKLQTP KKVLRTQFKK
130 140 150 160 170 180
AKFSEIIGQE EAKKKCRIIM KYLENPKLFG EWAPKNVLFY GPPGTGKTLM ARALATETNS
190 200 210 220 230 240
SFILVKAPEL IGEHVGDASK MIRELYQRAS ESAPCIVFID ELDAIGLSRE YQSLRGDVSE
250 260 270 280 290 300
VVNALLTELD GIKENEGVVT IAATNNPAML DPAIRSRFEE EIEFKLPNDE ERLKIMELYA
310 320 330 340 350 360
KKMPLPVKAN LKEFVEKTKG FSGRDIKEKF LKPALHRAIL EDRDYVSKED LEWALKKILG
370
NRREAPQHLY L