Q58839

PR
Gene name
fen
Protein name
Flap endonuclease 1
Names
FEN-1, Flap structure-specific endonuclease 1
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_1444
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

62-140 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q58839

Entry ID Method Resolution Chain Position Source
1A76 X-ray 200 A A 1-326 PDB
1A77 X-ray 200 A A 1-326 PDB
AF-Q58839-F1 Predicted AlphaFoldDB

No variants for Q58839

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58839

No associated diseases with Q58839

3 regional properties for Q58839

Type Name Position InterPro Accession
domain XPG, N-terminal 1 - 101 IPR006085
domain XPG-I domain 140 - 224 IPR006086
conserved_site Helix-hairpin-helix motif, class 2 211 - 245 IPR008918

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
5'-3' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.
5'-flap endonuclease activity Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
magnesium ion binding Binding to a magnesium (Mg) ion.

2 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication, removal of RNA primer Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGVQFGDFIP KNIISFEDLK GKKVAIDGMN ALYQFLTSIR LRDGSPLRNR KGEITSAYNG
70 80 90 100 110 120
VFYKTIHLLE NDITPIWVFD GEPPKLKEKT RKVRREMKEK AELKMKEAIK KEDFEEAAKY
130 140 150 160 170 180
AKRVSYLTPK MVENCKYLLS LMGIPYVEAP SEGEAQASYM AKKGDVWAVV SQDYDALLYG
190 200 210 220 230 240
APRVVRNLTT TKEMPELIEL NEVLEDLRIS LDDLIDIAIF MGTDYNPGGV KGIGFKRAYE
250 260 270 280 290 300
LVRSGVAKDV LKKEVEYYDE IKRIFKEPKV TDNYSLSLKL PDKEGIIKFL VDENDFNYDR
310 320
VKKHVDKLYN LIANKTKQKT LDAWFK