Q587J6

PR
Gene name
L1td1 (Ecat11)
Protein name
LINE-1 type transposase domain-containing protein 1
Names
ES cell-associated protein 11
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:381591
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-230 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q587J6

Entry ID Method Resolution Chain Position Source
AF-Q587J6-F1 Predicted AlphaFoldDB

46 variants for Q587J6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs28080135 12 Q>H No EVA
rs1132378783 28 A>S No EVA
rs265002176 36 S>R No EVA
rs3394714601 37 E>D No EVA
rs28080133 108 L>V No EVA
rs28080132 113 D>E No EVA
rs28080131 147 G>E No EVA
rs28080130 152 R>H No EVA
rs215187245 163 S>G No EVA
rs28080129 163 S>I No EVA
rs28080129 163 S>N No EVA
rs213141632 167 W>G No EVA
rs235586781 176 R>Q No EVA
rs28080128 178 A>P No EVA
rs217450083 179 S>R No EVA
rs253919956 217 G>R No EVA
rs253919956 217 G>S No EVA
rs32052312 284 R>K No EVA
rs218098786 307 A>S No EVA
rs259083073 316 I>V No EVA
rs3394589629 325 E>VFLLCKSSPLD* No EVA
rs28080104 336 R>W No EVA
rs28080103 346 E>D No EVA
rs581977358 373 G>S No EVA
rs3388696497 398 I>M No EVA
rs256215005 400 F>L No EVA
rs3388695554 413 V>I No EVA
rs28080100 417 T>M No EVA
rs28080097 464 G>R No EVA
rs3388694063 472 L>M No EVA
rs3388682920 484 D>V No EVA
rs265316559 505 T>M No EVA
rs222908825 511 R>G No EVA
rs238490114 514 V>A No EVA
rs28080096 516 Q>P No EVA
rs3388694509 522 A>T No EVA
rs3388695573 525 A>T No EVA
rs3388700339 533 E>A No EVA
rs28080095 536 K>R No EVA
rs3388697086 537 R>K No EVA
rs3388696496 545 Q>* No EVA
rs3388696161 552 K>R No EVA
rs3388694127 553 I>F No EVA
rs28080094 567 S>A No EVA
rs3388694111 570 D>N No EVA
rs224323227 667 S>A No EVA

No associated diseases with Q587J6

3 regional properties for Q587J6

Type Name Position InterPro Accession
domain L1 transposable element, dsRBD-like domain 211 - 275 IPR035300-1
domain L1 transposable element, dsRBD-like domain 718 - 779 IPR035300-2
domain L1 transposable element, RRM domain 619 - 713 IPR043636

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

1 GO annotations of molecular function

Name Definition
single-stranded RNA binding Binding to single-stranded RNA.

1 GO annotations of biological process

Name Definition
transposition, RNA-mediated Any process involved in a type of transpositional recombination which occurs via an RNA intermediate.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5T7N2 L1TD1 LINE-1 type transposase domain-containing protein 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MSGVQSKAAR LQKERKEKLS ADRERKTATS LCLKHSEVPA SMMKQFNALM EMQEVMFAEM
70 80 90 100 110 120
RETYKNDIKE MLLKRTAPWV KHLEERIGQQ EGDAISERPK PGEKVEELSS GTDEDTENLT
130 140 150 160 170 180
VRSKKGKQDK AKPLNSSHVL KSSLERGGEA LRGEHGRCGE SSSLVDWKNA NEKPAREASC
190 200 210 220 230 240
QSEENRLKAP KESPPEGGAG ATLRLAADFS AATLDVGRQW SQVFRLLKEK ELEPELQCSV
250 260 270 280 290 300
KLAFKCDGEA NVFSDLHSLR QFTSRKPFLR ELLKDVFPQN EGGRRNELRE RLGKTLGDTK
310 320 330 340 350 360
HEARRIASDS LSFLFIKEVE VASPEVKTYK EETLDRKNKG TLKKQEGEEE EISETQGEET
370 380 390 400 410 420
SEGETSELGE EEGSESEEEE ESSESEEEEE SSESAEEIGF ISLVVDSESE EEVNRKTASQ
430 440 450 460 470 480
TKKKETFHGL KELAFSYLVW DSKKKKLVRC QEGGAAAAST QRIGMPCLTL YLTSPSESLG
490 500 510 520 530 540
AGSDGPKSHS CTKLSALSQV TPLLTNIEKG RYKVPQTEEP TAKEADLILE TEENFKRGVI
550 560 570 580 590 600
SVIRQMQREV DKIKNIYVSD VLNMKSSLDD LNSLACTIEA RVSEQEDAVE GLTKDTMQLA
610 620 630 640 650 660
REIVDKERLR EREDRFRSSN IRVIGIPEKE NRENGAVDII KEVIEENFAE LEDQSLEIVS
670 680 690 700 710 720
AHRVPNSVDE HRLTPRHILV KFGSASDKQR VLKASRAKQE ITYRGSKIRL TADLSPGTID
730 740 750 760 770 780
ARSQWCGIIK ILQDEGFQPR ILYPAKLAFD FKGKTKIFFD IEEFKKFISD IPYLKDLLNN
IH