Q58597

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_1197
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-88 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q58597

Entry ID Method Resolution Chain Position Source
4RRF X-ray 170 A A/B/C/D/E/F 1-141 PDB
4RRG X-ray 193 A A/B/C/D 1-141 PDB
AF-Q58597-F1 Predicted AlphaFoldDB

No variants for Q58597

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58597

No associated diseases with Q58597

6 regional properties for Q58597

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 273 - 482 IPR002314
domain Anticodon-binding 503 - 597 IPR004154
domain Aminoacyl-tRNA synthetase, class II 221 - 496 IPR006195
domain Threonyl-tRNA synthetase, editing domain, archaea 1 - 136 IPR015011
domain Threonine-tRNA ligase catalytic core domain 197 - 501 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 501 - 596 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKMLLIHSDY LEFEAKEKTK IAEETENLKG KLDECLACFI AVEREDENNP EGTAIGAVEE
70 80 90 100 110 120
IEKVANQLKV NNIVVYPYAH LSSDLSSPET AVKVLKDIES ILKERGYNVL RAPFGWYKAF
130 140 150 160 170 180
KISCKGHPLS ELSRKIVAKE EKKEEGEESK FYLLNPETEE IIELNENNIN IIKDEELLAL
190 200 210 220 230 240
AKHELGIREH KEHDEPPHVK FIKEKDICSY EEASDPGHFR WYPKGKLMRD LLADYVYNLV
250 260 270 280 290 300
VNMGAMPVET PIMYDLGNPA IREHADKFGE RQYRFRQGNK ELMLRFAACF GQFMMKKDMY
310 320 330 340 350 360
LLPRYLPLKL YELSTYSFRY EQRGELVGLK RLRCFTMPDM HTVCLNLEQA MEEFEKQFWE
370 380 390 400 410 420
CLKTGDDLNL SYSVIFRFTK DFFDEHRDWF FKIAKEYKNK YGKDVILEIL PKRKHYWVGK
430 440 450 460 470 480
VDIAVIDSLG RPIENPTVQI DVESAKRFDI KVHTNEGEIY PIILHCSPTG SIERVLCGLL
490 500 510 520 530 540
EKAAIEAEKG NAPMLPVWLS PIQVRVIPVA ERHYDYALKV AEKLRENNIR ADFDDREESV
550 560 570 580 590 600
SKKIRNAGKE WVPYVVVIGD EEMESDKLTV TIREKSTLKK PYKEKMTLDE LIERIKKETA
610
NYPYRPLPLP IRCSLQPKFH