Q58576
Gene name |
pan |
Protein name |
Proteasome-activating nucleotidase |
Names |
PAN, Proteasomal ATPase, Proteasome regulatory ATPase, Proteasome regulatory particle |
Species |
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) |
KEGG Pathway |
mja:MJ_1176 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q58576
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3H43 | X-ray | 210 A | A/B/C/D/E/F/G/H/I/J/K/L | 74-150 | PDB |
| 3H4M | X-ray | 311 A | A/B/C | 155-430 | PDB |
| 3IPM | X-ray | 400 A | O/P/Q/R/S/T/U | 424-430 | PDB |
| AF-Q58576-F1 | Predicted | AlphaFoldDB |
No variants for Q58576
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q58576 | |||||
No associated diseases with Q58576
5 regional properties for Q58576
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AAA+ ATPase domain | 172 - 311 | IPR003593 |
| domain | ATPase, AAA-type, core | 176 - 309 | IPR003959 |
| conserved_site | ATPase, AAA-type, conserved site | 279 - 297 | IPR003960 |
| domain | Proteasomal ATPase OB C-terminal domain | 64 - 118 | IPR032501 |
| domain | AAA ATPase, AAA+ lid domain | 331 - 373 | IPR041569 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| proteasome regulatory particle, base subcomplex | The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. |
| proteasome-activating nucleotidase complex | A homohexameric complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| CTPase activity | Catalysis of the reaction: CTP + H2O = CDP + H+ + phosphate. May or may not be coupled to another reaction. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| proteasome-activating activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| proteasomal protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. |
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| protein unfolding | The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVFEEFISTE | LKKEKKAFTE | EFKEEKEIND | NSNLKNDLLK | EELQEKARIA | ELESRILKLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LEKKELEREN | LQLMKENEIL | RRELDRMRVP | PLIVGTVVDK | VGERKVVVKS | STGPSFLVNV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SHFVNPDDLA | PGKRVCLNQQ | TLTVVDVLPE | NKDYRAKAME | VDERPNVRYE | DIGGLEKQMQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EIREVVELPL | KHPELFEKVG | IEPPKGILLY | GPPGTGKTLL | AKAVATETNA | TFIRVVGSEL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VKKFIGEGAS | LVKDIFKLAK | EKAPSIIFID | EIDAIAAKRT | DALTGGDREV | QRTLMQLLAE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MDGFDARGDV | KIIGATNRPD | ILDPAILRPG | RFDRIIEVPA | PDEKGRLEIL | KIHTRKMNLA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EDVNLEEIAK | MTEGCVGAEL | KAICTEAGMN | AIRELRDYVT | MDDFRKAVEK | IMEKKKVKVK |
| EPAHLDVLYR |