Q58559
Gene name |
rpa (MJ1159) |
Protein name |
Replication factor A |
Names |
RF-A, RP-A, Replication factor A protein 1, Replication protein A, Single-stranded DNA-binding protein, mjaSSB |
Species |
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) |
KEGG Pathway |
mja:MJ_1159 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q58559
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3DM3 | X-ray | 240 A | A/B/C | 170-274 | PDB |
| AF-Q58559-F1 | Predicted | AlphaFoldDB |
No variants for Q58559
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q58559 | |||||
No associated diseases with Q58559
4 regional properties for Q58559
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type | 78 - 153 | IPR004365-1 |
| domain | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type | 187 - 266 | IPR004365-2 |
| domain | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type | 291 - 398 | IPR004365-3 |
| domain | Replication factor A, C-terminal | 513 - 597 | IPR013955 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| metal ion binding | Binding to a metal ion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| double-strand break repair via homologous recombination | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. |
| response to ionizing radiation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIGDYERFKQ | LKKKVAEALN | ISEEELDRMI | DKKIEENGGI | ILKDAALMMI | AKEHGVYGEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KNDEEFLISD | IEEGQIGVEI | TGVITDISEI | KTFKRRDGSL | GKYKRITIAD | KSGTIRMTLW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DDLAELDVKV | GDVIKIERAR | ARKWRNNLEL | SSTSETKIKK | LENYEGELPE | IKDTYNIGEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SPGMTATFEG | EVISALPIKE | FKRADGSIGK | LKSFIVRDET | GSIRVTLWDN | LTDIDVGRGD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YVRVRGYIRE | GYYGGLECTA | NYVEILKKGE | KIESEEVNIE | DLTKYEDGEL | VSVKGRVIAI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SNKKSVDLDG | EIAKVQDIIL | DNGTGRVRVS | FWRGKTALLE | NIKEGDLVRI | TNCRVKTFYD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| REGNKRTDLV | ATLETEVIKD | ENIEAPEYEL | KYCKIEDIYN | RDVDWNDINL | IAQVVEDYGV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NEIEFEDKVR | KVRNLLLEDG | TGRIRLSLWD | DLAEIEIKEG | DIVEILHAYA | KERGDYIDLV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IGKYGRIIIN | PEGVEIKTNR | KFIADIEDGE | TVEVRGAVVK | ILSDTLFLYL | CPNCRKRVVE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IDGIYNCPIC | GDVEPEEILR | LNFVVDDGTG | TLLCRAYDRR | VEKMLKMNRE | ELKNLTIEMV |
| 610 | 620 | 630 | 640 | ||
| EDEILGEEFV | LYGNVRVEND | ELIMVVRRVN | DVDVEKEIRI | LEEME |