Q58477

PR
Gene name
serS (MJ1077)
Protein name
Type-2 serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_1077
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

80-175 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58477

Entry ID Method Resolution Chain Position Source
AF-Q58477-F1 Predicted AlphaFoldDB

No variants for Q58477

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58477

No associated diseases with Q58477

2 regional properties for Q58477

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 310 - 489 IPR002314
domain Serine-tRNA ligase type 2, tRNA-binding domain 3 - 165 IPR041293

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLTFDLDGK IIFSKELSEE AKNAVEEVLK NADSIFLKGV PKGKENEASK IKSYEFEGNI
70 80 90 100 110 120
LKLKIASGTY TRAHEGLIRL RKPLAEKLGR NFRIGVRGIE IDNYVITIET DEDKAKKLEG
130 140 150 160 170 180
IKVPECEAKV EGNKIILTFK DIGESELKRN IIDRAIKFVK TELEKEEEDL TFKVCKIPPG
190 200 210 220 230 240
TIVSEYKAKR KITFDKDPTD VAEKLGWVKK FPGRGQWFYT PPITALFRAL EELIVEEVVK
250 260 270 280 290 300
KIGFQECLFP KLIPLEIMYK MRYLEGLPEG MYYVCPPKRE PELFKEFVNE MMIKKEIPIE
310 320 330 340 350 360
KLKNLLRDPG YVLAPAQCEP FYQFFEGEVI DVDKPIMFFD RSGWTYRWEG GGARGLDRVN
370 380 390 400 410 420
EFLRVECVWI GSPEFVEETR DKTLKYAEKL AEKLDLEYWV EVGDDPFYLE GRKKEDRGIE
430 440 450 460 470 480
FPDVPKYEMR LWLPHIKDER KGVAVTSANV HGTHFVEGFR IKDYKGRRVW TGCTGYGITR
490 500 510 520
WVVGYLAQYG FNFDDWHPII KKKIKKLPEV PQLITWPKKD E