Q58475

PR
Gene name
trpE (MJ1075)
Protein name
Anthranilate synthase component 1
Names
AS, ASI
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_1075
EC number
4.1.3.27: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

149-227 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58475

Entry ID Method Resolution Chain Position Source
AF-Q58475-F1 Predicted AlphaFoldDB

No variants for Q58475

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58475

No associated diseases with Q58475

2 regional properties for Q58475

Type Name Position InterPro Accession
domain Anthranilate synthase component I, N-terminal 9 - 157 IPR006805
domain Chorismate-utilising enzyme, C-terminal 202 - 461 IPR015890

Functions

Description
EC Number 4.1.3.27 Oxo-acid-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
anthranilate synthase activity Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIIKKIKMDV CPLDVYEQIR GENTFLLESA EGVPKVARYS ILGKAEGKVI FKNGKLKVES
70 80 90 100 110 120
FTEFGDKAKD LEGKYECPLD ALREVRNEYL KYIDISNIEP IPRFKGGLVG YLSYDIIRYW
130 140 150 160 170 180
IDLSNINPKP INDLKFPDAE FFIVKDFISF DLKEKVINLI AEDDEGIREL ERIIKNAKIG
190 200 210 220 230 240
NNDNKEEKTT ENKDLKIKSN MSKEEFIEAV KKAKEYIFAG DIFQVVLSRR IEIDLDNLDH
250 260 270 280 290 300
LKIYKKVREI NPSPYMYYLD FGDRKIIGSS PEILVRTDYK DNKRLVITRP IAGTIRRGKT
310 320 330 340 350 360
EEEDKELEKK LLSDEKERAE HVMLVDLARN DIGKISKFGT VEVTDFMIIE KYSHVQHIVS
370 380 390 400 410 420
NVVGELKDNY DSFLAVKATF PAGTLSGAPK VRAMEIIEEL EKTWRGPYGG GVGYFGWDDL
430 440 450 460 470
MDLAITIRTF VISKNKGYIQ VGAGIVADSI PENEWEETER KGMANVKTIE SLLK