Q58445

PR
Gene name
rpo1N
Protein name
DNA-directed RNA polymerase subunit Rpo1N
Names
DNA-directed RNA polymerase subunit A'
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_1042
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

259-333 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58445

Entry ID Method Resolution Chain Position Source
AF-Q58445-F1 Predicted AlphaFoldDB

No variants for Q58445

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58445

No associated diseases with Q58445

17 regional properties for Q58445

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 318 - 460 IPR000722-1
domain RNA polymerase, alpha subunit 911 - 944 IPR000722-2
domain Hint domain C-terminal 871 - 917 IPR003586
domain Hint domain N-terminal 458 - 557 IPR003587
domain Intein DOD homing endonuclease 616 - 783 IPR004042
domain Homing endonuclease, LAGLIDADG 727 - 818 IPR004860
ptm Intein N-terminal splicing region 460 - 537 IPR006141
domain Intein 524 - 537 IPR006142-1
domain Intein 613 - 625 IPR006142-2
domain Intein 770 - 785 IPR006142-3
domain Intein 888 - 905 IPR006142-4
domain RNA polymerase, N-terminal 208 - 972 IPR006592
domain RNA polymerase Rpb1, domain 3 947 - 1110 IPR007066
domain RNA polymerase Rpb1, domain 1 8 - 316 IPR007080
domain RNA polymerase Rpb1, domain 5 1249 - 1325 IPR007081
domain RNA polymerase Rpb1, domain 4 1136 - 1242 IPR007083
domain Intein C-terminal splicing region 889 - 912 IPR030934

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
intein-mediated protein splicing The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MERYEIPKEI GEIMFGLLSP DYIRQMSVAK IVTPDTYDED GYPIDGGLMD TRLGVIDPGL
70 80 90 100 110 120
VCKTCGGRIG ECPGHFGHIE LAKPVIHIGF AKTIYKILKA VCPHCGRVAI SETKRKEILE
130 140 150 160 170 180
KMEKLERDGG NKWEVCEEVY KEASKVTICP HCGEIKYDIK FEKPTTYYRI DGNEEKTLTP
190 200 210 220 230 240
SDVREILEKI PDEDCILLGL NPEVARPEWM VLTVLPVPPV TVRPSITLET GERSEDDLTH
250 260 270 280 290 300
KLVDIIRINN RLEENIEGGA PNLIIEDLWN LLQYHVNTYF DNEAPGIPPA KHRSGRPLKT
310 320 330 340 350 360
LAQRLKGKEG RFRYNLAGKR VNFSSRTVIS PDPCLSINEV GVPEVVAKEL TVPEKVTKYN
370 380 390 400 410 420
IERIRQLLRN GSEKHPGVNY VIRKMIGRDG TEQEYKVKIT ESNKDFWAEN IREGDIVERH
430 440 450 460 470 480
LMDGDIVLYN RQPSLHRMSI MAHRVRVLPY RTFRHNLCVC VDGDTTVLLD GKLIKIKDLE
490 500 510 520 530 540
DKWKDVKVLT SDDLNPKLTS LSKYWKLNAD EYGKKIYKIK TELGREIIAT EDHPFYTTNG
550 560 570 580 590 600
RKRCGELKVG DEVIIYPNDF PMFEDDNRVI VDEEKIKKVI NNIGGTYKNK IINELKDRKL
610 620 630 640 650 660
IPLTYNDQKA SILARIVGHV MGDGSLIINN KNSRVVFRGD IEDLKTIKED LKELGYDGEE
670 680 690 700 710 720
IKLHEGETEI TDYNGKKRII KGKGYSFEVR KKSLCILLKA LGCVGGDKTK KMYGIPNWIK
730 740 750 760 770 780
TAPKYIKKEF LSAYFGSELT TPKIRNHGTS FKELSFKIAK IEEIFDEDRF IKDIKEMLKE
790 800 810 820 830 840
FGIELKVRVE EGNLRKDGYK TKVYVASIYN HKEFFGRIGY TYANKKETLA RYAYEYLLTK
850 860 870 880 890 900
EKYLKDRNIK KLENNTKFIT FDKFIKEKCL KNGFVKEKIV SIEETKVDYV YDITTISETH
910 920 930 940 950 960
NFIANGFLTG NCPPYNADFD GDEMNLHVPQ SEEARAEAEA LMLVEKHILS PRFGGPIIGA
970 980 990 1000 1010 1020
IHDFISGAYL LTSNYFTKDE ATLILRSGGI KDELWEPDKV ENGVPLYSGK KIFSKALPKG
1030 1040 1050 1060 1070 1080
LNLRYKAKIC RKCDVCKKEE CEYDAYVVIK DGELIKGVID KNGYGAEAGL ILHTIVKEFG
1090 1100 1110 1120 1130 1140
PEAGRKFLDS ATKMAIRAVM LRGFTTGIDD EDLPEEALKE IEKVLDEAEE KVKEIIEKYE
1150 1160 1170 1180 1190 1200
RGELELLPGL NLEESREAYI SNVLREARDK AGAIAERYLG LDNHAVIMAV TGARGNILNL
1210 1220 1230 1240 1250 1260
TQMAACLGQQ SVRGKRIFRG YRGRVLPHFE KGDLGARSHG FVRSSYKKGL SPTEFFFHAM
1270 1280 1290 1300 1310 1320
GGREGLVDQA VRTAQSGYMQ RRLINALQDL KTEFDGTVRD SRGIMIQFKY GEDGIDPMLA
1330 1340
DRGKAVNIDR IIDKVKMKYN Q