Q58444

PR
Gene name
rpo2N
Protein name
DNA-directed RNA polymerase subunit Rpo2N
Names
DNA-directed RNA polymerase subunit B''
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_1040
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

395-466 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58444

Entry ID Method Resolution Chain Position Source
AF-Q58444-F1 Predicted AlphaFoldDB

No variants for Q58444

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58444

No associated diseases with Q58444

8 regional properties for Q58444

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 675 - 1068 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 921 - 933 IPR007121
domain RNA polymerase Rpb2, domain 7 1070 - 1145 IPR007641
domain RNA polymerase Rpb2, domain 2 140 - 290 IPR007642-1
domain RNA polymerase Rpb2, domain 2 373 - 409 IPR007642-2
domain RNA polymerase, beta subunit, protrusion 28 - 453 IPR007644
domain RNA polymerase Rpb2, domain 3 468 - 536 IPR007645
domain DNA-directed RNA polymerase, beta subunit, external 1 domain 546 - 613 IPR019462

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAIMRELVDA YFKEHGLIDH QIESYNDFVE NRLQKIIDEV GYIETEITGG YKVKLGKIKV
70 80 90 100 110 120
GKPVIKEADG SIRPITPMEA RIRDLTYSVP LYLEMTPIIG EGEDAREGET VEVYIGELPV
130 140 150 160 170 180
MLGSKICHLY GKSREELIDL GEDPEDPFGY FIINGTEKVL ITQEDLIPNR ILCEKAERSG
190 200 210 220 230 240
KIVDVAKVFS TRHGFRALCT VERHPDGLLY ATFPGMPGQI PLVILMKALG AETDKDIIES
250 260 270 280 290 300
IDDERFFMEI VLNIQEIREE HNINSPEDAL EFIGKRVAPG QAKDYRLKRA ETVLCNYLLP
310 320 330 340 350 360
HLGVTKEDFP KKIRFLGIMA RNALELYFGY RGEDDKDHYA YKRAKLAGDL MEDLFRYAFS
370 380 390 400 410 420
QLVKDIKYQL ERQTLRNKTP SIQAAVRSDI LTERIKHAMA TGTWVGGKTG VSQLLDRTSY
430 440 450 460 470 480
LATNSQLRRI VSPLSRSQPH FEARELHGTH WGKICPSETP EGPNCGLVKN FAIMCKVTRE
490
EDDSKVIELL KSFGINVS