Q58293

PR
Gene name
trm5b (MJ0883)
Protein name
tRNA (guanine(37)-N1)-methyltransferase Trm5b
Names
M1G-methyltransferase, tRNA [GM37] methyltransferase
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_0883
EC number
2.1.1.228: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

29-104 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q58293

Entry ID Method Resolution Chain Position Source
2YX1 X-ray 220 A A/B 1-336 PDB
2ZZM X-ray 265 A A 1-336 PDB
2ZZN X-ray 295 A A/B 1-336 PDB
3AY0 X-ray 305 A A/B 1-336 PDB
AF-Q58293-F1 Predicted AlphaFoldDB

No variants for Q58293

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58293

No associated diseases with Q58293

2 regional properties for Q58293

Type Name Position InterPro Accession
domain SAM-dependent methyltransferase TRM5/TYW2-type 96 - 335 IPR030382
domain tRNA methyltransferase 5, N-terminal 4 - 48 IPR040601

Functions

Description
EC Number 2.1.1.228 Methyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
tRNA (guanine(37)-N(1))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine.
tRNA (guanine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine.
tRNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.

2 GO annotations of biological process

Name Definition
tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.
tRNA N1-guanine methylation The process whereby a guanine in tRNA is methylated at position N1 of the guanine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPLCLKINKK HGEQTRRILI ENNLLNKDYK ITSEGNYLYL PIKDVDEDIL KSILNIEFEL
70 80 90 100 110 120
VDKELEEKKI IKKPSFREII SKKYRKEIDE GLISLSYDVV GDLVILQISD EVDEKIRKEI
130 140 150 160 170 180
GELAYKLIPC KGVFRRKSEV KGEFRVRELE HLAGENRTLT IHKENGYRLW VDIAKVYFSP
190 200 210 220 230 240
RLGGERARIM KKVSLNDVVV DMFAGVGPFS IACKNAKKIY AIDINPHAIE LLKKNIKLNK
250 260 270 280 290 300
LEHKIIPILS DVREVDVKGN RVIMNLPKFA HKFIDKALDI VEEGGVIHYY TIGKDFDKAI
310 320 330
KLFEKKCDCE VLEKRIVKSY APREYILALD FKINKK