Q58050

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_0633
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

339-417 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q58050

Entry ID Method Resolution Chain Position Source
AF-Q58050-F1 Predicted AlphaFoldDB

No variants for Q58050

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q58050

No associated diseases with Q58050

3 regional properties for Q58050

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 41 - 52 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 13 - 669 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 709 - 838 IPR013155

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMVMIDFKEI EKKWQKRWEE AKIFEANPDD REKFFITAAF PYLNGVLHAG HLRTFTIPEV
70 80 90 100 110 120
VARFQRMKNK NVLWTFGYHV TGTPILGLAE LIKNRDEKTI WAYTELHGIP KEELLELTTP
130 140 150 160 170 180
EKIVEYFSKK AEEAFKRMGF SLDWRRNFKT DDKVFNKFIE WQFHKLKEKG LIVKGSHPVR
190 200 210 220 230 240
YCPRCDNPVE DHDILVGENA TLVEYILIKF TTEDGCIMPM ATLRPETVFG VTNVWVNPEA
250 260 270 280 290 300
TYVKAKVYLE KETENGIELI ENGIWIMAKE CAEKLKHQDR KIEIIEEFKG EQLINKKVKN
310 320 330 340 350 360
PVTGKEVPIL PAKFVKTNIG TGCVMSVPAH APYDYIALRD LGLVDEIGLI PLINVPGYGK
370 380 390 400 410 420
YPAKEIVEKM GIKSQEEEDK LEEATKKIYK DEFHKGVLNE NCLDYEGIPV REIKDKLTKD
430 440 450 460 470 480
LIDKGLAEIM YEFSEEKVIC RCGTPCIVKM VKGQWFIKYS DEKWKELAHK CIDKMRFIPE
490 500 510 520 530 540
NLRQVFHEKI DWMKDKACVR RRGLGTKFPF EEGWVIESLS DSTIYPAYYT VAKYINQHNI
550 560 570 580 590 600
KPEQLTLELF DYVFLGKGDV DKIAKETGIP KDIIEGMRKE FIYYYPVDWR CSAKDLIPNH
610 620 630 640 650 660
LTFYIFNHVA IFPEEFWPRG IVVNGYVTIE GKKLSKSKGP VLPVLEVAEK FGADVGRFYI
670 680 690 700 710 720
TTCAELPQDA DIKFKEMENT KKVLERLYLF AKEIAERRGE TGEEFSYIDK WLLSRLYKAV
730 740 750 760 770 780
KQYDEYMENF ELRKAGILLY QLLDDLKWYR RRGGNNIRVL EEFLEVIIKL MMPFTPHLCE
790 800 810 820 830 840
EMWEILGKEG FVSLAKFPEV KEEFINDEIE KGEEYLKAVM EDIKEIINVA KVQPKRIYLY
850 860 870 880 890 900
TADDWKYEIL KIIKENEGKT IKELMPIIMK NPEFRKYGKE IPKLVNQLIK LNAEIINEVE
910 920 930 940
VLENAKEFLK KEVGVEDIII NGEDKANKKR VAIPFKPAIY LE