Q57X81

PR
Gene name
JBP2 (Tb927.7.4650)
Protein name
Bifunctional helicase and thymine dioxygenase JBP2
Names
J-binding protein 2, TbJBP2
Species
Trypanosoma brucei brucei (strain 927/4 GUTat101)
KEGG Pathway
tbr:Tb927.7.4650
EC number
1.14.11.6: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

166-236 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q57X81

Entry ID Method Resolution Chain Position Source
AF-Q57X81-F1 Predicted AlphaFoldDB

No variants for Q57X81

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q57X81

No associated diseases with Q57X81

4 regional properties for Q57X81

Type Name Position InterPro Accession
domain SNF2, N-terminal 530 - 785 IPR000330
domain Helicase, C-terminal 871 - 1032 IPR001650
domain Helicase superfamily 1/2, ATP-binding domain 515 - 714 IPR014001
domain 2OGFeDO JBP1/TET, oxygenase domain 308 - 420 IPR024779

Functions

Description
EC Number 1.14.11.6 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

8 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent activity, acting on DNA Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.
ATP-dependent chromatin remodeler activity An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
ferrous iron binding Binding to a ferrous iron ion, Fe(II).
thymine dioxygenase activity Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2.

2 GO annotations of biological process

Name Definition
base J metabolic process The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J.
transcription-coupled nucleotide-excision repair The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPMFMDGASQ VLQQVLQTVL VTSEPAIVIP GSFLGELDVI VDEAKNHGMK LVSIPKGGIT
70 80 90 100 110 120
ILPPIPMSES SLTRLCKDYY GLKTDAERLA LFSNLEETFP TAPGVSLPCR LLYHPRDYIC
130 140 150 160 170 180
RIVHLCAELV TASDEEYQKA YDIVPLLHIR PVQNVCEELR RQFRAGALTQ RLPLGQRVDV
190 200 210 220 230 240
QFKRTVVHLD GSMDPFPRNA AEAAVNIAPV ALDAVDDIYE GFDVTGTEVV DIPTGKVSEY
250 260 270 280 290 300
LSEKDFELVT EDSVLLDPTG KRVQAIFIRG GIDKDICRRA AADVEGVATK QNMRRLTNGG
310 320 330 340 350 360
VRNPDTGILG YYDYLNNPTK RKCRMTEFTR RNWGKIIGPC GELLQLLDQL YKENAPDHYE
370 380 390 400 410 420
LQRRVIPPEY MLFNTVFSTV SVNKNFRTAV HRDKGDFRGG LTALCVLDGN YEGCYLALKS
430 440 450 460 470 480
ARKAFCLQVG DVLFFDSSLE HGNTEVHNRE GSWRRISIVC YLRCGLMSHT CETERSMRLR
490 500 510 520 530 540
NQIMSDRLHA DSADSVVNLN GVTGHLPPLC IPFKIAKTLS LTQHAALRFV SRRIKEGDGC
550 560 570 580 590 600
VLALTMGLGK TLVSLTICYS YIYNNGPCDI LIVAPKTLLQ HWMQEAKKWK DYGLVFPGFI
610 620 630 640 650 660
VLNNVDSSSF EDDLSNYEQQ GTTTNPKKSY VFVINPGYIK SFLSRVKGFR PALIVVDEGH
670 680 690 700 710 720
CISSKESKLR EVLDSLYCSA RVVLTGTPVQ NNAEELYRLV GWVDDKVHST LPQRDFNEFS
730 740 750 760 770 780
NSINRYVNGD DSAFCDALFA QRYIHEWMSP YVFTVMKVDL PPLHDYIIIC NFSAVQQKMF
790 800 810 820 830 840
EERIKVDATD NLLCLKASEH RPYHLSTHPL CFLGFLTGIW RTGQVDIEEE PGEFEELGTY
850 860 870 880 890 900
RLSRDDDALA KDCSSLLENG KLADFVALSG KLTALISILH SIFEKMEKAV IFSQYIGSQD
910 920 930 940 950 960
FIARTLTAYK ISVVTIRGKD CQQRRRRVVE MFRDDKNVLC LVVSTQIGAY GLDLTAANHV
970 980 990 1000 1010 1020
ILWDTWWNPQ VESQAIARCY RQNQSKAVIA YKLASGFEDA TVLKAQARKR ALFKCLINEE
1030 1040 1050 1060 1070
TSQVVPGHDL VDYTSSEEDD DRRHLWETLK TCTLEGGKPA VTKIIRNIDT VKSERWI