Q57986

PR
Gene name
MJ0566
Protein name
Fe(2+) transporter FeoB
Names
Ferrous iron transport protein B
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_0566
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

153-224 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q57986

Entry ID Method Resolution Chain Position Source
2WJG X-ray 220 A A/B 1-184 PDB
2WJH X-ray 210 A A/B 1-165 PDB
2WJI X-ray 190 A A/B 1-165 PDB
2WJJ X-ray 240 A A/B 1-167 PDB
AF-Q57986-F1 Predicted AlphaFoldDB

No variants for Q57986

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q57986

No associated diseases with Q57986

8 regional properties for Q57986

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 1 - 157 IPR005225
domain GTP binding domain 6 - 26 IPR006073-1
domain GTP binding domain 54 - 69 IPR006073-2
domain Ferrous iron transport protein B, C-terminal 452 - 504 IPR011640
domain Nucleoside transporter/FeoB GTPase, Gate domain 348 - 442 IPR011642-1
domain Nucleoside transporter/FeoB GTPase, Gate domain 509 - 639 IPR011642-2
domain FeoB-type guanine nucleotide-binding (G) domain 3 - 165 IPR030389
domain FeoB, cytosolic helical domain 175 - 264 IPR041069

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ferrous iron transmembrane transporter activity Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other.
GTP binding Binding to GTP, guanosine triphosphate.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKSYEIALIG NPNVGKSTIF NALTGENVYI GNWPGVTVEK KEGEFEYNGE KFKVVDLPGV
70 80 90 100 110 120
YSLTANSIDE IIARDYIINE KPDLVVNIVD ATALERNLYL TLQLMEMGAN LLLALNKMDL
130 140 150 160 170 180
AKSLGIEIDV DKLEKILGVK VVPLSAAKKM GIEDLKKAIS IAVKDKKTAE IKYPNFEPYI
190 200 210 220 230 240
KKITSILQKD EDLKKYNLRY LAIKLLENDK YVEEIVKNSK VWNELKPVLD SIINELSKKY
250 260 270 280 290 300
GEAELGIVEE RYKVIDKIVK EVMKKTSGKL TTTEMLDDVL TDEKIGTLLI IPFLWMLFKF
310 320 330 340 350 360
TFDVSKPFSA MIEYFFGFLS EVVKSSISNK FIASLLADGI ISGVGAVLVF FPILAFLFFA
370 380 390 400 410 420
ISFLEDSGYM ARIPFITDRI MNKFGLPGKA VISMVMGFGC NVPAIMATRT IEDEKDRILT
430 440 450 460 470 480
ILINPLLSCS ARLPIYALFA GALFSKYQGV VILSMYALGV VLALITAFLF RKLIFKTSPS
490 500 510 520 530 540
YLIVELPPYH IPHLNVVLKN TWERVYDFLR KAGTIIVFGV ILVWVLSVYG PSGYLGEEVF
550 560 570 580 590 600
ENPQLIANSW VAVIGKTLAP LFSPMGWDWR ACSALVFGII AKEVVVGSLA MLYGTGEENL
610 620 630 640 650 660
SSVIAHAFSP VSAYAFMAFS LIYLPCIATL AVIKQEIGWK WALFAVTYEM ILAYVVALVI
SVIGNLLF