Q57834

PR
Gene name
tyrS (MJ0389)
Protein name
Tyrosine--tRNA ligase
Names
Tyrosyl-tRNA synthetase, TyrRS
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_0389
EC number
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

38 structures for Q57834

Entry ID Method Resolution Chain Position Source
1J1U X-ray 195 A A 1-306 PDB
1U7D X-ray 265 A A/B 1-306 PDB
1U7X X-ray 300 A A/B 1-306 PDB
1ZH0 X-ray 190 A A 1-306 PDB
1ZH6 X-ray 250 A A 1-306 PDB
2AG6 X-ray 190 A A 1-306 PDB
2HGZ X-ray 250 A A 2-306 PDB
2PXH X-ray 197 A A 1-306 PDB
2ZP1 X-ray 170 A A 1-306 PDB
3D6U X-ray 220 A A 1-306 PDB
3D6V X-ray 220 A A 1-306 PDB
3N2Y X-ray 249 A A/B 1-306 PDB
3QE4 X-ray 230 A A/B 1-306 PDB
4HJR X-ray 250 A A/B 1-306 PDB
4HJX X-ray 291 A A/B 1-306 PDB
4HK4 X-ray 230 A A 1-306 PDB
4HPW X-ray 200 A A 1-306 PDB
4ND6 X-ray 200 A A 1-306 PDB
4ND7 X-ray 200 A A 1-306 PDB
4NDA X-ray 170 A A 1-306 PDB
4NX2 X-ray 200 A A 1-306 PDB
4PBR X-ray 190 A A 1-306 PDB
4PBS X-ray 201 A A 1-306 PDB
4PBT X-ray 190 A A 1-306 PDB
5L7P X-ray 190 A A/B 1-306 PDB
5N5U X-ray 160 A A 1-306 PDB
5N5V X-ray 230 A A/B/C/D/E/F/G/H 1-306 PDB
5NSF X-ray 243 A A/B/C/D 1-306 PDB
5U36 X-ray 303 A A/B 1-306 PDB
6WRK X-ray 195 A A 1-306 PDB
6WRN X-ray 160 A A 1-306 PDB
6WRQ X-ray 185 A A 1-306 PDB
6WRT X-ray 155 A A 1-306 PDB
7C5C X-ray 172 A A 1-306 PDB
7CKG X-ray 205 A A/B 1-306 PDB
7CKH X-ray 179 A A/B 1-306 PDB
7YNW X-ray 279 A A/B 1-306 PDB
AF-Q57834-F1 Predicted AlphaFoldDB

No variants for Q57834

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q57834

No associated diseases with Q57834

1 regional properties for Q57834

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 37 - 46 IPR001412

Functions

Description
EC Number 6.1.1.1 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tyrosine-tRNA ligase activity Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDEFEMIKRN TSEIISEEEL REVLKKDEKS AYIGFEPSGK IHLGHYLQIK KMIDLQNAGF
70 80 90 100 110 120
DIIILLADLH AYLNQKGELD EIRKIGDYNK KVFEAMGLKA KYVYGSEFQL DKDYTLNVYR
130 140 150 160 170 180
LALKTTLKRA RRSMELIARE DENPKVAEVI YPIMQVNDIH YLGVDVAVGG MEQRKIHMLA
190 200 210 220 230 240
RELLPKKVVC IHNPVLTGLD GEGKMSSSKG NFIAVDDSPE EIRAKIKKAY CPAGVVEGNP
250 260 270 280 290 300
IMEIAKYFLE YPLTIKRPEK FGGDLTVNSY EELESLFKNK ELHPMDLKNA VAEELIKILE
PIRKRL