Q57829

PR
Gene name
cas3 (cas3'', MJ0384)
Protein name
CRISPR-associated endonuclease Cas3-HD
Names
CRISPR-associated ssDNA/ssRNA endonuclease Cas3-HD
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_0384
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

194-244 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q57829

Entry ID Method Resolution Chain Position Source
3S4L X-ray 230 A A 1-244 PDB
AF-Q57829-F1 Predicted AlphaFoldDB

No variants for Q57829

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q57829

No associated diseases with Q57829

1 regional properties for Q57829

Type Name Position InterPro Accession
domain Ciliogenesis-associated TTC17-interacting protein, dimerization/docking domain 306 - 345 IPR047501

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MILGEIMEVL AFKNQSLIDH VNDMVKYWER IKYRYLKTIK RALEALNIKL DIEKVDEFMK
70 80 90 100 110 120
ILIKLHDIGK ASKIYQRAII NDQEKLMGFR HELVSAYYTY HILLKKFGDK NLAFIGALTV
130 140 150 160 170 180
MLHHEPIIMG QIRNLKKKEL TAEVVLDKLK KFDGMIEDFE DLIKKLIGYS IGDIIKNDSN
190 200 210 220 230 240
KDDIIRFVIE MSVRARHTPN SEKLRFIVGT LLLPLVMCDY KGAESREGKA PKFAEVLEVE
SYVI