Q57822

PR
Gene name
cas4 (MJ0377)
Protein name
CRISPR-associated exonuclease Cas4
Names
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_0377
EC number
3.1.12.1: Exodeoxyribonucleases producing 3'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

96-168 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q57822

Entry ID Method Resolution Chain Position Source
AF-Q57822-F1 Predicted AlphaFoldDB

No variants for Q57822

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q57822

No associated diseases with Q57822

1 regional properties for Q57822

Type Name Position InterPro Accession
domain Ciliogenesis-associated TTC17-interacting protein, dimerization/docking domain 306 - 345 IPR047501

Functions

Description
EC Number 3.1.12.1 Exodeoxyribonucleases producing 3'-phosphomonoesters
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
manganese ion binding Binding to a manganese ion (Mn).
single-stranded DNA 5'-3' exodeoxyribonuclease activity Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule.

2 GO annotations of biological process

Name Definition
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
DNA catabolic process, exonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MENYLEEELI IGGIEINYLY VCKTKLWYFV RGITMEQESD FVDLGKFLHE KSYFGEEKEV
70 80 90 100 110 120
QIGSIKIDFI KKRDVIEIHE VKRGKQMEKA HIMQVLYYIY YLNSLGIKSK AILHYPKLKE
130 140 150 160
IKEIELKENN KEEIKRAIKE IEYIKSLKEP PEPIYQKICK NCAYYELCFI