Q57681

PR
Gene name
glyS
Protein name
Glycine--tRNA ligase
Names
Glycyl-tRNA synthetase, GlyRS
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_0228
EC number
6.1.1.14: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

211-282 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q57681

Entry ID Method Resolution Chain Position Source
AF-Q57681-F1 Predicted AlphaFoldDB

No variants for Q57681

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q57681

No associated diseases with Q57681

4 regional properties for Q57681

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 158 - 234 IPR002314
domain Anticodon-binding 483 - 574 IPR004154
domain Aminoacyl-tRNA synthetase, class II 4 - 481 IPR006195
domain Glycyl-tRNA synthetase-like core domain 9 - 340 IPR033731

Functions

Description
EC Number 6.1.1.14 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glycine-tRNA ligase activity Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

1 GO annotations of biological process

Name Definition
glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKDIYEKIM DLAKRRGYLW SSFEIYGGIA GFVDYGPLGC LLKNNIISKF REQYIIKEGF
70 80 90 100 110 120
YEIESPTVTP YEVLKASGHV DNFTDPIVEC KNCLESFRAD HLIEEFVDVD TEGKTLKELD
130 140 150 160 170 180
ELIRKHNIRC PKCGGELGEV KKFNLMFVTS IGPGGKRTGY MRPETAQGIF IQFRRLAQFF
190 200 210 220 230 240
RNKLPFGVVQ IGKSYRNEIS PRQGVIRLRE FTQAEIEYFV HPERKEHEKF DLVKDEVVPL
250 260 270 280 290 300
LPAERQMDEN LSDDEKVIKI SIGEAVEKGI IRHQTIAYFI ALTKRFLEAI GIDKDKIRFR
310 320 330 340 350 360
QHLPNEMAHY AIDCWDAEIY TERFGWIECV GIADRTDYDL RSHSAHSGVE LSVFVELDEE
370 380 390 400 410 420
REIETYEINL NYKVVGKIFK KDTKAIEAYI NNLSEKEKEE FVKNIENDGK VIINIDGKEF
430 440 450 460 470 480
EILKDYVEIK KVKKVIKGEK VIPHVIEPSY GIDRITYCLL EHSYREEEDR VYLDLKPSIA
490 500 510 520 530 540
PIKAYVLPLV NKDDMPKIAK EIEQMLRENG IIAEYDDSGA IGRRYMRADE IGVPFCITVD
550 560 570
GQTLEDRTVT VRERNTREQV RVKIDELVDY LKERLKE