Q571H0
PR
Gene name |
Urb1 (Kiaa0539, Npa1) |
Protein name |
Nucleolar pre-ribosomal-associated protein 1 |
Names |
URB1 ribosome biogenesis 1 homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:207932 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q571H0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q571H0-F1 | Predicted | AlphaFoldDB |
No variants for Q571H0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q571H0 | |||||
No associated diseases with Q571H0
1 regional properties for Q571H0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | v-SNARE, coiled-coil homology domain | 49 - 136 | IPR042855 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
| maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGVPKRKASE | GPSSAASPAG | TVKRTRAEEF | TGVRFKTLLK | DAQGPGPALE | AFVSAAKKLP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QEDMCDVVEG | YIKISMECAE | IFQLLSGEKR | PESEMLLIFQ | AFEAILLRTA | SDLTHFHVVG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ANIVKKLLYN | HMKLLCESLY | ASGYRMARAC | LDLMTAMVTQ | GPEAARDVCS | SLDLNKKALF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ALVTKRDSKG | VHDVRLAYIQ | FALSFLIAGD | DNTIGQVLEI | KEFIPCIFSS | GIKEDKISTI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NILLSTLKTK | VIHNKNITKT | QKVRFFTGQF | LNHIAALYNW | NGITDVTPEK | PEISAEEAGK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AMVRDLVHNF | LMDLCCSRKH | GISFYDASLG | TSGRGGNLTL | LHFLLSLKTA | AGDDLVASLV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VSILKVCPDL | LTKYFKEVTF | SFLPRVKSTW | LNNVKLLNKI | YEAQPEISPA | FWTREFIPLP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RLLAMVMVTT | VPLVCNKIMF | TQALNLDSIP | VKHSALSLIS | DILKRALKTV | DHCLDKETWQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DSDVYTAEMM | EEFVQLFREA | LGKILPDLNT | VIWVWQSFKK | QEIKEDHEKG | KKSSSKTPAV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SKAAQHDVAE | TILLKSVLLQ | VICLYQQVVP | HVIMQYNFDF | SKLLKGIISE | QGPSQEVPPI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LQHHMLKVAL | ELPANKFLWL | KAQEGPEAEI | IGGERSVFYL | LMKMFVNSNH | LQLKSSTKLL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IMKILRDTGV | FEHTWRELEL | WLEHLDSTAE | ERKEAVIQFL | ERILLTLVMN | PYSYTDKASE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| FVQEASTLQA | SMGKQDADDV | SIPISHIDDV | LDMVDVLVEG | SEGLDEDIGF | LLNEDMILLT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FPFSALVPAA | LEARNKLLLG | TDCEAGESIM | AYMTAVLTDL | LHTQRDPLAL | CLLLQSYDKF |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EPVSLLCGQQ | LAQFHRYYSL | WIPAQAQEAL | PLQVSSSSGP | CTLPPSSCFS | TLLQTAYESQ |
| 910 | 920 | 930 | 940 | 950 | 960 |
| TLGDKSVQAQ | LLAAVPSLAL | QHMLRSAKQV | LLYLKSTVEN | FSQLGRSVGP | ALLQSLLGLL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KQLVIHAERL | DAQNQQKLEA | ARAESDLFLD | MESVASLELA | TDKTIEELLL | AILKHPTLET |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| WFLALEQKAL | PPHTLSPILV | KLLAAHFSAG | VLQLLVASSP | ILHKLGQLGL | LAKYSEAITQ |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| SVLIELRTRT | LNSTSTPKTL | PQLEALRELH | PYMEGVQIRE | VTLALLALPE | AHLLTQQGTQ |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| SLGKERHLSS | LGKTLVQLLA | SSHQDQLQSS | ELLWCAEYVR | GLGALLPTLA | EHELDTVFLQ |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| TLQKDPVLAP | VVPEGVLEYC | LARRTQTALG | IASLLLQYSG | THLVKFELWC | GQPGVGPTLQ |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| EHLDDFFPLI | HVYLQHRAQG | SFMRPTGVSS | AVTPVLKALW | RQVRDRFFHI | TGPSKDALHL |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| EALAQLIPFA | RTKDLHVLMD | HLPNTLRTLS | NHKSWTLADS | VSAALAESAE | ELGSWRKTLL |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| RSCIQWLAVS | FSGREPEDEN | TQEHEKAMLV | RLSELLHAVK | EVDPGDWQQF | VKTGLKFRYH |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| DLTFLKTLLS | ATKLLYGPES | SGRTKLVQLS | VVHMMLTQHS | LFLPTMLSSE | EEETPDSGVK |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| ETLLDLMSTV | VRLCPSVCQS | SHFAVLLGTY | SATLSVLDQK | ILLLLRAYEQ | NNLSLISFRV |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| LLWGPAAVEH | HKTCRSLGKS | LWQQPSVGDI | LRLLDPDRMM | QTILHFPQYR | KLLPTEDTGE |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| PLVFKDKTAR | VDLDSLYDPC | FLLHLFGELT | RPEFVVDCRK | FLDSNALGLT | VAALSSYDPQ |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| MRAAAYYVLA | AYYSHLEGAR | FREQSQVLYL | LDVVRNGIRT | PNLRLPFTVA | LFIAKAAVQI |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| LKPEEHMYWK | ISKFLLSHEN | LNMDKLPGFY | QFFYSSDFQQ | KTEQEWVLEI | LRQGIRDKHC |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| YELCSRRGVF | HIILSFFNSP | LCDEVAQNWI | LEILQNVAHI | TRSAYEVIRD | YSLLTWVLHI |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| LESRFVETQL | LSNVISLLHT | LWVTNLGNKA | PEERSQPPGQ | VGSQESEKML | ALHMVSEFLY |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| VLIALTKHLR | PTLASAQLMN | FFWTLESVLS | YRATIIKLFK | DMGRFTVNKV | ALSTKDVLIL |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| LHKWSLIERD | TKLQGELKAV | IEQHQAKDLM | KMLKDKSRPV | VAAQARGPRG | RKRRHGGLEE |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| TAEPQLEASC | LEKCKDLLRA | TLTHWGPGDP | LPGPTQGSVG | QTIPKSKTLS | SAHAAVSLVA |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| SWVLRSLAER | PVSRAEVTRL | LDWLKSHILP | QPMVVADLLG | DSAVKTGIFK | LYNHHCSAQG |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| LVGPAQDVAC | KFSTVMLQLL | VAQGRKESPF | HSVAEALCLD | SLNEKEEAKR | APAAFLVSLY |
| 2230 | 2240 | 2250 | 2260 | 2270 | |
| VKDMWLGAQQ | PDTFLAHIRM | VCEAAKDVPL | DEPEAIVVLC | RNVDSSAQCL | TRSR |