AiPD: Autoinhibited Protein Database

Q567U6

Gene name	CCDC93
Protein name	Coiled-coil domain-containing protein 93
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:54520
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

265-338 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

265-338 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q567U6

Entry ID	Method	Resolution	Chain	Position	Source
8F2U	EM	353 A	N	1-631	PDB
AF-Q567U6-F1	Predicted				AlphaFoldDB

472 variants for Q567U6

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs982727301 CA54577817	2	G>R		No	ClinGen TOPMed gnomAD
CA348336037 CA1844996 rs572505275	3	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767427061 CA1844997	3	L>W		No	ClinGen ExAC gnomAD
CA348336033 rs1294772841	4	P>L		No	ClinGen gnomAD
CA1844994 rs770677051	5	R>T		No	ClinGen ExAC gnomAD
CA348336000 rs772677010	9	G>D		No	ClinGen ExAC TOPMed gnomAD
CA1844992 rs772677010	9	G>V		No	ClinGen ExAC TOPMed gnomAD
rs769588404 CA1844991	10	Q>P		No	ClinGen ExAC gnomAD
rs375536207 CA348335988	11	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs375536207 CA1844990	11	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs370651764 CA1844989	12	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs370651764 CA54577751	12	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA1844986 rs373187880	13	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA54573276 rs1053431530	17	T>A		No	ClinGen Ensembl
rs747844112 CA348335897	22	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1573535617 CA348335889	23	Q>H		No	ClinGen Ensembl
CA348335879 rs1208756681	25	V>I		No	ClinGen TOPMed
rs1558808201 CA348335869	26	K>R		No	ClinGen Ensembl
CA348335840 rs1335593085	30	I>T		No	ClinGen TOPMed gnomAD
rs1380102236 CA348335843	30	I>V		No	ClinGen TOPMed gnomAD
rs1237247088 CA348335836	31	L>V		No	ClinGen TOPMed
CA1844970 rs544335383	32	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA54573212 rs544335383	32	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA348335765 rs1441562401	42	A>T		No	ClinGen gnomAD
CA1844968 rs746561328	43	R>T		No	ClinGen ExAC gnomAD
CA348335742 rs1160273219	45	K>T		No	ClinGen TOPMed
rs762485014 CA54573178	48	S>P		No	ClinGen Ensembl
CA348335717 rs1281141557	49	P>H		No	ClinGen gnomAD
rs775124006 CA1844947	62	T>A		No	ClinGen ExAC gnomAD
rs761242541 CA54571554	62	T>S		No	ClinGen Ensembl
rs1428343767 CA348335465	63	T>A		No	ClinGen gnomAD
rs1426097668 CA348335460	63	T>I		No	ClinGen gnomAD
CA1844945 rs749838435	66	F>I		No	ClinGen ExAC gnomAD
CA1844944 rs778086495	67	D>G		No	ClinGen ExAC gnomAD
CA54571531 rs1044736618	68	V>I		No	ClinGen TOPMed
CA54571524 rs930315541	70	V>F		No	ClinGen Ensembl
rs1450844390 CA348335402	72	L>V		No	ClinGen TOPMed
rs1314760969 CA348335394	73	L>F		No	ClinGen TOPMed
TCGA novel	75	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772074897 CA54571497	75	Q>H		No	ClinGen TOPMed gnomAD
rs920314790 CA54571503	75	Q>L		No	ClinGen Ensembl
TCGA novel	77	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1844941 rs781337040	78	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs375816525 CA1844940	79	T>M	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	84	I>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs960590162 CA54566444	85	A>G		No	ClinGen TOPMed
TCGA novel	90	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1468601392 CA348334880	90	I>V		No	ClinGen gnomAD
TCGA novel	91	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1177482387 CA348334851	92	S>L		No	ClinGen gnomAD
rs763988055 CA1844912	95	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA1844913 rs763988055	95	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1439712820 CA348334752	101	H>R		No	ClinGen gnomAD
CA1844910 rs767103390	102	Q>H		No	ClinGen ExAC gnomAD
CA348334741 rs1197967632	102	Q>R		No	ClinGen TOPMed
CA348334722 rs1181326878	103	L>P		No	ClinGen gnomAD
CA54566381 rs1033599760 TCGA novel	104	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed gnomAD NCI-TCGA
TCGA novel	105	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773912518 CA1844907	109	Q>E		No	ClinGen ExAC gnomAD
CA348334614 rs1558804077	111	M>L		No	ClinGen Ensembl
CA348334593 rs1354461276	112	D>G		No	ClinGen gnomAD
CA1844905 rs763147634	112	D>N		No	ClinGen ExAC TOPMed gnomAD
rs776841417 CA1844904	114	I>F		No	ClinGen ExAC gnomAD
CA348334563 rs776841417	114	I>V		No	ClinGen ExAC gnomAD
rs867011947 CA54566323	115	H>N		No	ClinGen Ensembl
CA348334552 rs1450690524	115	H>R		No	ClinGen gnomAD
CA1844902 rs747367448	116	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	117	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755451281 CA54566296	118	P>A		No	ClinGen Ensembl
CA1844901 rs775715315	120	V>F		No	ClinGen ExAC TOPMed gnomAD
CA1844881 rs775777300	122	W>R		No	ClinGen ExAC gnomAD
rs1166423716 CA348334093	123	L>P		No	ClinGen gnomAD
rs200821912 CA1844879	124	V>G		No	ClinGen ExAC gnomAD
rs774550662 CA1844878	125	K>E		No	ClinGen ExAC gnomAD
rs777697897 CA1844876	126	R>*		No	ClinGen ExAC gnomAD
rs777697897 CA1844877	126	R>G		No	ClinGen ExAC gnomAD
rs560250128 CA1844873	126	R>L		No	ClinGen 1000Genomes ExAC gnomAD
rs560250128 CA1844874	126	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs779713937 CA1844870	127	A>D		No	ClinGen ExAC gnomAD
CA1844869 rs779713937	127	A>G		No	ClinGen ExAC gnomAD
CA1844872 rs754607494	127	A>S		No	ClinGen ExAC
CA1844871 rs754607494	127	A>T		No	ClinGen ExAC
rs779713937 CA348334057	127	A>V		No	ClinGen ExAC gnomAD
CA348334048 rs1488159170	128	I>M		No	ClinGen TOPMed gnomAD
rs757837500 CA1844868	128	I>V		No	ClinGen ExAC TOPMed gnomAD
CA348334032 rs1223988540	129	E>D		No	ClinGen gnomAD
rs1266295183 CA348334039	129	E>G		No	ClinGen gnomAD
rs1377348465 CA348334022	130	T>R		No	ClinGen TOPMed
rs1558801559 CA348333991	133	E>*		No	ClinGen Ensembl
CA348333980 rs757971766	133	E>D		No	ClinGen ExAC TOPMed gnomAD
CA54561869 rs113727191	133	E>G		No	ClinGen Ensembl
TCGA novel	133	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM387077 rs764651148 CA348333968 CA1844866	134	M>I	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1558801527 CA348333979	134	M>V		No	ClinGen Ensembl
CA1844864 rs753072596	137	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs548297852 CA1844863	138	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA1844862 rs760000721 COSM3713369	139	R>C	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA1844861 rs374030570	139	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA348333860 rs1294978561	140	S>F		No	ClinGen gnomAD
rs1309220292 CA348333841	141	Y>F		No	ClinGen TOPMed
TCGA novel	142	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348333821 rs1384635969	143	V>I		No	ClinGen TOPMed
CA348333822 rs1384635969	143	V>L		No	ClinGen TOPMed
CA1844859 rs763029252	146	F>Y		No	ClinGen ExAC gnomAD
rs1466936673 CA348333772	147	Q>*		No	ClinGen gnomAD
rs930202687 CA54561765	147	Q>R		No	ClinGen TOPMed gnomAD
rs1573524114 CA348333758	148	K>E		No	ClinGen Ensembl
rs773220121 CA1844858	148	K>T		No	ClinGen ExAC gnomAD
CA1844857 rs769743231	150	Y>H		No	ClinGen ExAC gnomAD
CA54561734 rs986213493	151	S>I		No	ClinGen Ensembl
rs748087247 CA1844856	154	E>K		No	ClinGen ExAC TOPMed gnomAD
rs765185486 CA1844838	155	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1304953779 CA348333530	156	D>H		No	ClinGen gnomAD
CA1844837 rs761987086	156	D>V		No	ClinGen ExAC gnomAD
CA348333514 rs1181360503	157	D>G		No	ClinGen TOPMed
CA348333516 rs1258223503	157	D>Y		No	ClinGen gnomAD
CA348333508 rs1364608510	158	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs985326993 CA54560982	164	K>N		No	ClinGen TOPMed
rs1352281642 CA348333453	165	A>V		No	ClinGen gnomAD
CA54560981 rs748384094	166	I>N		No	ClinGen Ensembl
rs768595029 CA1844835	168	T>P		No	ClinGen ExAC gnomAD
CA348333416 rs146559024	171	D>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA1844834 rs146559024	171	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	172	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750813537 CA348332864	175	V>A		No	ClinGen ExAC gnomAD
CA1844804 rs750813537	175	V>E		No	ClinGen ExAC gnomAD
CA348332865 rs1164589529	175	V>M		No	ClinGen TOPMed
rs1288732412 CA348332857	176	Y>C		No	ClinGen gnomAD
rs757543411 CA348332846	178	P>A		No	ClinGen ExAC TOPMed gnomAD
rs753884678 CA1844801	178	P>H		No	ClinGen ExAC gnomAD
CA348332843 rs753884678	178	P>L		No	ClinGen ExAC gnomAD
CA1844802 rs757543411	178	P>T		No	ClinGen ExAC TOPMed gnomAD
VAR_054108 CA1844800 rs33975708	179	R>C		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs146353723 CA1844798	179	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs146353723 CA1844799	179	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs759191385 CA1844796	180	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs767493504 CA1844797	180	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1323196016 CA348332822	182	Y>*		No	ClinGen gnomAD
CA1844795 rs547383441	182	Y>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1844794 rs770482744	183	K>R		No	ClinGen ExAC TOPMed gnomAD
CA1844793 rs762731633	184	R>C		No	ClinGen ExAC TOPMed gnomAD
rs773023570 COSM1613330 CA1844792	184	R>H	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1450869566 CA348332791	187	G>E		No	ClinGen gnomAD
CA1844791 rs769391785	187	G>R		No	ClinGen ExAC gnomAD
TCGA novel	189	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1382438779 CA348332783	189	E>K		No	ClinGen gnomAD
rs1196411222 CA348332764	191	L>P		No	ClinGen gnomAD
rs200757900 CA1844789	192	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA1844788 rs200757900	192	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA348332752 rs746214930	193	D>E		No	ClinGen ExAC gnomAD
CA348332757 rs1245596635	193	D>N		No	ClinGen gnomAD
CA1844786 rs375214898	194	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs757450696 COSM1172797 CA1844785	197	R>*	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
COSM202216 CA1844784 rs754008225	197	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM1399024 rs531145241 CA54554494	200	A>G	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA54554492 rs758924778	201	T>A		No	ClinGen TOPMed gnomAD
CA348332704 rs1489536910	201	T>I		No	ClinGen TOPMed
CA348332706 rs758924778	201	T>P		No	ClinGen TOPMed gnomAD
CA54554478 rs187777209	202	L>F		No	ClinGen 1000Genomes
rs778000234 CA1844783	203	L>V		No	ClinGen ExAC gnomAD
CA1844781 rs752835316	205	Y>H		No	ClinGen ExAC gnomAD
rs1307411031 CA348332354	208	R>G		No	ClinGen TOPMed gnomAD
rs1285924926 CA348332348	208	R>S		No	ClinGen TOPMed
rs1381401803 CA348332344	209	Y>C		No	ClinGen TOPMed
CA1844767 rs746438552	210	G>A		No	ClinGen ExAC TOPMed gnomAD
CA1844765 rs34095554 VAR_054109	213	R>C		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs138746784 CA1844764	213	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs138746784 CA348332315	213	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA348332280 rs1335393824	218	E>Q		No	ClinGen TOPMed gnomAD
TCGA novel	220	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1321539819 CA348332247	220	A>V		No	ClinGen TOPMed gnomAD
CA348332243 rs1235740136	221	E>A		No	ClinGen gnomAD
rs773628715 COSM1005862 CA1844745	224	K>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs200815626 CA1844744	225	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs368632876 CA1844741	226	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1043289000 CA54548921	227	L>I		No	ClinGen Ensembl
VAR_054110 rs17512204 CA1844740	228	P>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA348332198 rs1291469998	228	P>S		No	ClinGen gnomAD
CA1844738 rs758476502	230	G>E		No	ClinGen ExAC TOPMed gnomAD
rs750213336 CA1844737	231	L>P		No	ClinGen ExAC gnomAD
rs765174029 CA1844736	232	S>P		No	ClinGen ExAC TOPMed gnomAD
rs191929076 CA1844735	234	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1372095143 CA348332165	234	T>I		No	ClinGen TOPMed
CA1844732 rs760173703	236	K>E		No	ClinGen ExAC gnomAD
TCGA novel	237	A>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA54548872 rs866209565	239	A>V		No	ClinGen gnomAD
rs766862811 CA1844729	241	E>K		No	ClinGen ExAC
rs1369643221 CA348332089	245	L>F		No	ClinGen TOPMed
TCGA novel	245	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1220973239 CA348332080	247	A>T		No	ClinGen TOPMed
CA348332038 rs1199078015	251	Q>*		No	ClinGen gnomAD
CA1844707 rs146540432	252	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA1844706 rs188870650	252	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA348332019 rs1302154012	254	Q>*		No	ClinGen gnomAD
rs762227659 CA1844705	254	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs779620059 CA1844704	255	S>*		No	ClinGen ExAC TOPMed gnomAD
rs779620059 CA54548719	255	S>L		No	ClinGen ExAC TOPMed gnomAD
CA348332000 rs1230812804	257	M>I		No	ClinGen TOPMed
CA54548713 rs974310684	257	M>T		No	ClinGen TOPMed
rs1175833541 CA348332005	257	M>V		No	ClinGen gnomAD
CA1844702 rs377352172	259	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	260	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348331970 rs1219313595	261	T>I		No	ClinGen TOPMed
TCGA novel	261	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348331969 rs577490713	262	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1844700 rs577490713	262	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	262	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs867273470 CA54548699	263	M>I		No	ClinGen Ensembl
rs368407933 CA1844699	263	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	264	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA54548696 rs553650037	265	N>D		No	ClinGen Ensembl
CA348331949 rs1254707617	265	N>S		No	ClinGen TOPMed gnomAD
rs183129016 CA1844698	266	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA348331937 rs1485737961	267	E>K		No	ClinGen gnomAD
CA1844682 rs772434663	269	R>C		No	ClinGen ExAC TOPMed gnomAD
rs140577157 CA1844681	269	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA348331617 rs1449527706	270	L>F		No	ClinGen gnomAD
rs1266146892 CA348331605	271	T>N		No	ClinGen gnomAD
rs377718905 CA1844679	272	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs377718905 CA1844678	272	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs769537277 CA1844676	273	S>G		No	ClinGen ExAC TOPMed gnomAD
CA1844674 rs780811895	274	S>A		No	ClinGen ExAC TOPMed gnomAD
CA1844673 rs754693427	275	V>M		No	ClinGen ExAC TOPMed gnomAD
CA348331554 rs1325428178	276	G>S		No	ClinGen gnomAD
rs374241278 CA1844671	278	I>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs374241278 CA1844672	278	I>T	Variant assessed as Somatic; 4.692e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA1844670 rs369512557	280	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs764669710 CA1844668	283	S>Y		No	ClinGen ExAC gnomAD
rs1169145371 CA348331459	284	A>S		No	ClinGen gnomAD
TCGA novel	285	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1476732135 CA348331445	285	E>G		No	ClinGen TOPMed gnomAD
TCGA novel	286	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375420124 CA54548283	286	I>T		No	ClinGen Ensembl
CA54548280 rs951050424	287	K>N		No	ClinGen TOPMed
CA348331400 rs1193851003	289	I>F		No	ClinGen gnomAD
rs767844842 CA1844665	291	S>C		No	ClinGen ExAC TOPMed gnomAD
rs767844842 CA348331385	291	S>F		No	ClinGen ExAC TOPMed gnomAD
COSM1200105 CA1844663 rs372750359	292	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA54543693 rs900834730	297	Q>*		No	ClinGen TOPMed
CA348330328 rs900834730	297	Q>E		No	ClinGen TOPMed
CA348330306 rs1483446810	297	Q>H		No	ClinGen TOPMed
CA348330314 rs1374481901	297	Q>P		No	ClinGen gnomAD
rs777649677 CA54543690	298	S>C		No	ClinGen Ensembl
CA54543691 rs1040756389	298	S>P		No	ClinGen TOPMed
rs1354341144 CA348330291	299	E>G		No	ClinGen gnomAD
CA348330295 rs1446450248	299	E>K		No	ClinGen gnomAD
rs762882454 CA1844643	300	L>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
rs149812101 CA54543685	302	A>V		No	ClinGen ESP TOPMed gnomAD
CA348330257 rs1157855167	304	E>D		No	ClinGen gnomAD
rs1358269449 CA348330260	304	E>G		No	ClinGen gnomAD
rs769855202 CA1844642	305	S>R		No	ClinGen ExAC TOPMed gnomAD
rs765129613 CA1844641	306	P>S		No	ClinGen ExAC gnomAD
CA1844640 rs761788327	308	K>I		No	ClinGen ExAC gnomAD
CA54543679 rs925540598	309	L>*		No	ClinGen Ensembl
rs1474846863 CA348330224	309	L>F		No	ClinGen gnomAD
rs902942102 CA54543676	315	H>Q		No	ClinGen TOPMed gnomAD
VAR_035499	315	H>R	a colorectal cancer sample; somatic mutation [UniProt]	No	UniProt
CA1844637 rs746828863	316	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1844636 rs774950823	316	R>H		No	ClinGen ExAC gnomAD
rs746828863 CA348330185	316	R>S		No	ClinGen ExAC TOPMed gnomAD
CA1844634 rs745363342	317	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs200247512 CA1844635 COSM362044	317	R>W	lung Variant assessed as Somatic; 0.0 impact. breast [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA54543672 rs867173315	320	I>N		No	ClinGen Ensembl
rs1226908460 CA348330156	321	S>A		No	ClinGen gnomAD
CA348330155 rs1355392634 COSM3735590	321	S>F	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs778603020 CA1844633	322	L>V		No	ClinGen ExAC gnomAD
CA348330118 rs1416117673	326	I>T		No	ClinGen gnomAD
rs151101188 CA348330111	327	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA1844632 rs151101188	327	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	328	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348330106 rs1213740768	328	Q>R		No	ClinGen TOPMed
TCGA novel	329	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1844630 rs781772141	331	K>R		No	ClinGen ExAC TOPMed gnomAD
CA1844628 rs751965097	332	H>R		No	ClinGen ExAC gnomAD
rs755230211 CA1844629	332	H>Y		No	ClinGen ExAC gnomAD
CA1844627 rs780137457	333	L>F		No	ClinGen ExAC gnomAD
rs926437344 CA54543663	335	E>G		No	ClinGen gnomAD
CA348330062 rs1476249179	335	E>K		No	ClinGen gnomAD
rs368763445 CA1844609	337	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs368763445 CA1844610	337	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs780519084 CA1844608	338	A>V		No	ClinGen ExAC gnomAD
rs1480933728 CA348335645	341	T>I		No	ClinGen TOPMed
rs1254016298 CA348335650	341	T>P		No	ClinGen gnomAD
CA348335639 rs1203213192	342	S>N		No	ClinGen TOPMed gnomAD
CA348335637 rs1422185731	342	S>R		No	ClinGen TOPMed
CA1844607 rs758713336	345	A>G		No	ClinGen ExAC gnomAD
CA348335610 rs1251203733	347	Y>H		No	ClinGen gnomAD
rs972375174 CA54542199	348	N>Y		No	ClinGen TOPMed gnomAD
CA1844605 rs111848781	349	E>A		No	ClinGen ExAC gnomAD
CA54542196 rs111848781	349	E>G		No	ClinGen ExAC gnomAD
CA1844604 rs757273236	351	K>R		No	ClinGen ExAC TOPMed gnomAD
COSM1005860 CA1844603 rs753979004	353	T>M	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1376314496 CA348335293	358	K>R		No	ClinGen gnomAD
rs1175732311 CA348335272	361	S>N		No	ClinGen gnomAD
rs908015789 CA348335251	364	L>M		No	ClinGen TOPMed gnomAD
rs1183233860 CA348335249	364	L>Q		No	ClinGen gnomAD
rs757545240 CA1844585	365	D>E		No	ClinGen ExAC gnomAD
rs1421408246 CA348335246	365	D>H		No	ClinGen gnomAD
CA348335210 rs1485686657	369	A>V		No	ClinGen gnomAD
CA54541470 rs983638561	370	A>P		No	ClinGen TOPMed gnomAD
rs983638561 CA348335209	370	A>T		No	ClinGen TOPMed gnomAD
rs752637002 CA1844581	372	E>D		No	ClinGen ExAC gnomAD
rs756165776 CA1844582	372	E>K		No	ClinGen ExAC gnomAD
TCGA novel	374	I>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754761873 CA1844579	374	I>M		No	ClinGen ExAC gnomAD
rs767359277 CA1844580	374	I>T		No	ClinGen ExAC TOPMed gnomAD
CA1844577 rs766124263	375	E>D		No	ClinGen ExAC gnomAD
rs751983591 CA1844578	375	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs762745507 CA1844576	378	A>T		No	ClinGen ExAC gnomAD
CA348335155 rs1282918254	378	A>V		No	ClinGen TOPMed
rs368262892 CA1844575	380	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA1844553 rs767983584	381	S>R		No	ClinGen ExAC TOPMed gnomAD
CA348335121 rs1244107669	382	I>V		No	ClinGen gnomAD
rs771240780 CA1844550	388	A>T		No	ClinGen ExAC TOPMed gnomAD
CA54541176 rs558356235	390	V>A		No	ClinGen Ensembl
rs1573479415 CA348335071	390	V>L		No	ClinGen Ensembl
rs773425552 CA1844548	391	A>D		No	ClinGen ExAC TOPMed gnomAD
CA1844549 rs773425552	391	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	392	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348335062 rs1469766190	392	M>L		No	ClinGen gnomAD
TCGA novel	392	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	393	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769967352 CA1844547	393	N>S		No	ClinGen ExAC gnomAD
rs748253637 CA1844546	399	Q>E		No	ClinGen ExAC gnomAD
CA1844545 rs527316000	400	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA348334993 rs1230884784	401	Q>*		No	ClinGen gnomAD
rs1016389201 CA54541166	402	E>Q		No	ClinGen TOPMed gnomAD
rs1369322125 CA348334962	405	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs774975360 CA54541164	407	C>W		No	ClinGen TOPMed gnomAD
rs768880837 CA1844544	408	R>*		No	ClinGen ExAC gnomAD
CA1844542 rs780144445	408	R>P		No	ClinGen ExAC TOPMed gnomAD
rs780144445 CA1844543	408	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs750776665 CA1844513	409	E>D		No	ClinGen ExAC gnomAD
CA348334900 rs1257142132	409	E>K		No	ClinGen gnomAD
TCGA novel	409	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1844511 rs530152837	411	M>L		No	ClinGen 1000Genomes ExAC gnomAD
rs530152837 CA1844512	411	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1282612370 CA348334832	413	R>*		No	ClinGen gnomAD
CA348334827 rs775274028	413	R>L		No	ClinGen ExAC TOPMed gnomAD
CA1844510 rs775274028	413	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1352070814 CA348334802	415	Q>H		No	ClinGen gnomAD
CA54540771 rs1005389551	415	Q>R		No	ClinGen TOPMed gnomAD
CA348334788 rs1290697981	416	Q>P		No	ClinGen gnomAD
CA348334746 rs764469062	418	I>S		No	ClinGen ExAC TOPMed gnomAD
rs764469062 CA1844509	418	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1313187778 CA348334712	420	N>K		No	ClinGen gnomAD
rs1449756928 CA348334666	424	E>D		No	ClinGen gnomAD
TCGA novel	425	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1205569068 CA348334649	426	A>T		No	ClinGen TOPMed gnomAD
rs760836670 CA1844508	427	P>A		No	ClinGen ExAC TOPMed gnomAD
rs765211376 CA1844507	428	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1844505 COSM385672 rs138026247	428	R>H	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs138026247 CA1844506	428	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1844503 rs376640225	430	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	431	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754324382 CA1844491	433	T>I		No	ClinGen ExAC TOPMed gnomAD
CA348334495 rs1573477093	433	T>P		No	ClinGen Ensembl
rs1165607279 CA348334488	434	L>F		No	ClinGen gnomAD
CA54540377 rs1049951957	436	S>G		No	ClinGen TOPMed
CA348334478 rs1049951957	436	S>R		No	ClinGen TOPMed
rs1320333250 CA348334465	438	E>K		No	ClinGen TOPMed
rs1320333250 CA348334464	438	E>Q		No	ClinGen TOPMed
rs141821049 CA1844490	439	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA348334457 rs1417698438	439	P>S		No	ClinGen gnomAD
rs1212150342 CA348334439	442	T>A		No	ClinGen gnomAD
CA1844488 rs577755174	443	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1266566056 CA348334423	444	T>I		No	ClinGen TOPMed
CA54540363 rs774112868	445	S>F		No	ClinGen TOPMed
TCGA novel	445	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	446	A>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767451265 CA1844487	446	A>T		No	ClinGen ExAC gnomAD
CA54540359 rs912436800	448	T>A		No	ClinGen TOPMed
CA348334399 rs1305237881	448	T>I		No	ClinGen TOPMed gnomAD
CA348334403 rs912436800	448	T>P		No	ClinGen TOPMed
rs1214780614 CA348334395 COSM1613329	449	H>R	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
rs375460660 CA54540356	450	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA1844462 rs776136914	453	L>I		No	ClinGen ExAC gnomAD
rs768423918 CA1844461	453	L>P		No	ClinGen ExAC TOPMed gnomAD
rs149174692 CA1844459	456	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142085524 CA1844460	456	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA1844457 rs749776201	457	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	457	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778425253 CA1844456	458	N>D		No	ClinGen ExAC gnomAD
rs756485447 CA1844455	459	M>L		No	ClinGen ExAC TOPMed gnomAD
rs753167698 CA1844454	459	M>T		No	ClinGen ExAC gnomAD
rs781263452 CA1844453	461	K>T		No	ClinGen ExAC gnomAD
rs766432802 CA1844450	464	L>F		No	ClinGen ExAC gnomAD
VAR_054111 rs17047557 CA1844449	465	Y>H		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs750303114 CA1844448	467	I>M		No	ClinGen ExAC gnomAD
rs765217420 CA1844447	468	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA348334255 rs1467105888	468	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1364450989 CA348334250	469	L>S		No	ClinGen TOPMed
rs776531013 CA1844445	471	Q>H		No	ClinGen ExAC gnomAD
rs775146748 CA348333907	473	R>*		No	ClinGen ExAC gnomAD
CA1844422 rs775146748	473	R>G		No	ClinGen ExAC gnomAD
rs147959653 CA1844420	473	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs147959653 CA1844421	473	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs774041462 CA1844419	474	R>G		No	ClinGen ExAC gnomAD
CA54539166 rs775660660	474	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA1844418 rs770401792	476	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs144153360 CA1844417	476	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1844416 rs777035750	477	E>A		No	ClinGen ExAC TOPMed gnomAD
rs933475665 COSM333396 CA54539158	478	I>M	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1179777677 CA348333811	480	I>V		No	ClinGen gnomAD
CA1844415 rs768998173	481	L>S		No	ClinGen ExAC gnomAD
CA348333781 rs1319111930	482	H>Y		No	ClinGen TOPMed
CA1844414 rs747392111	483	R>C		No	ClinGen ExAC TOPMed gnomAD
rs780250232 CA1844413	483	R>H		No	ClinGen ExAC TOPMed gnomAD
CA1844412 rs758662628	484	K>E		No	ClinGen ExAC gnomAD
rs1014127039 CA54539148	484	K>M		No	ClinGen Ensembl
CA1844411 rs745926874	485	I>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	485	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348333726 rs1220113033	486	D>G		No	ClinGen TOPMed gnomAD
rs1220113033 CA348333722	486	D>V		No	ClinGen TOPMed gnomAD
CA348333683 rs1243577233	489	P>L		No	ClinGen TOPMed
CA348333679 rs1158227384	490	S>G		No	ClinGen gnomAD
rs778918390 CA1844410	491	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1844409 rs150518527	491	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	492	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1206757961 CA348333647	493	E>K		No	ClinGen TOPMed
rs763956132 CA1844407	494	L>I		No	ClinGen ExAC TOPMed gnomAD
rs372412683 CA1844406	496	Q>E		No	ClinGen ESP ExAC gnomAD
CA1844405 rs752603176	497	Y>*		No	ClinGen ExAC gnomAD
rs867740698 CA54539133	498	Q>*		No	ClinGen Ensembl
TCGA novel	499	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1844404 rs767245569	500	R>K		No	ClinGen ExAC TOPMed gnomAD
CA1844402 rs148434878	506	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs979411640 CA54539127	506	R>H		No	ClinGen TOPMed gnomAD
rs756042609 CA1844385	509	S>L		No	ClinGen ExAC gnomAD
CA1844384 rs752515553	512	H>Y		No	ClinGen ExAC gnomAD
CA348333357 rs1359361438	513	K>R		No	ClinGen gnomAD
TCGA novel	514	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1844382 rs754849739	515	T>I		No	ClinGen ExAC gnomAD
CA348333275 rs1211894354	524	T>N		No	ClinGen TOPMed
rs1573471535 CA348333263	526	D>G		No	ClinGen Ensembl
rs762519962 CA1844379	527	D>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	527	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1165497018 CA348333248	528	K>R		No	ClinGen gnomAD
rs1446618163 CA348333238	529	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1407297420 CA348333244	529	K>Q		No	ClinGen gnomAD
CA348333198 rs969718782	535	E>*		No	ClinGen gnomAD
CA54538618 rs969718782	535	E>K		No	ClinGen gnomAD
rs199804694 CA54538023	536	I>M		No	ClinGen Ensembl
CA54538021 rs1014200589	537	S>G		No	ClinGen TOPMed
CA1844361 rs754761942	542	I>V		No	ClinGen ExAC gnomAD
rs751467046 CA1844360	543	H>D		No	ClinGen ExAC gnomAD
rs1372571841 CA348333123	544	E>D		No	ClinGen gnomAD
rs1410684207 CA348333127	544	E>G		No	ClinGen gnomAD
TCGA novel	545	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1844338 rs778643662	550	M>V		No	ClinGen ExAC gnomAD
rs1026172454 CA54537675	553	P>A		No	ClinGen TOPMed gnomAD
rs376037036 CA54537672	554	A>T		No	ClinGen ESP TOPMed gnomAD
CA1844335 rs138708100	556	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1844336 rs372727967	556	R>W		No	ClinGen ESP ExAC gnomAD
rs755684889 CA54537667	557	D>E		No	ClinGen gnomAD
rs1229806585 CA348333033	557	D>N		No	ClinGen TOPMed gnomAD
CA348333001 rs1352896320	561	R>C		No	ClinGen gnomAD
CA1844334 rs140975342	561	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1168545543 CA348332994	562	Q>R		No	ClinGen TOPMed
rs1462851867 CA348332985	563	M>I		No	ClinGen TOPMed
CA1844333 rs147078459	563	M>L		No	ClinGen ESP ExAC gnomAD
rs766610084 CA1844332	564	E>K		No	ClinGen ExAC gnomAD
rs763379685 CA1844331	566	I>T		No	ClinGen ExAC gnomAD
CA348332957 rs1170004478	567	V>A		No	ClinGen TOPMed
TCGA novel	567	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1364318199 CA348332940	570	I>V		No	ClinGen TOPMed
rs147943059 CA1844329	571	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs761953219 CA1844328	573	S>G		No	ClinGen ExAC gnomAD
CA348332916 rs1402006925	573	S>N		No	ClinGen gnomAD
CA1844327 rs776901223	573	S>R		No	ClinGen ExAC gnomAD
TCGA novel	584	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779574804	617	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q567U6

No regional properties for Q567U6

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q567U6

Functions

		Description
EC Number
Subcellular Localization	Early endosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
early endosome	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name	Definition
endocytic recycling	The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
Golgi to plasma membrane transport	The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MGLPRGPEGQ	GLPEVETRED	EEQNVKLTEI	LELLVAAGYF	RARIKGLSPF	DKVVGGMTWC
70	80	90	100	110	120
ITTCNFDVDV	DLLFQENSTI	GQKIALSEKI	VSVLPRMKCP	HQLEPHQIQG	MDFIHIFPVV
130	140	150	160	170	180
QWLVKRAIET	KEEMGDYIRS	YSVSQFQKTY	SLPEDDDFIK	RKEKAIKTVV	DLSEVYKPRR
190	200	210	220	230	240
KYKRHQGAEE	LLDEESRIHA	TLLEYGRRYG	FSRQSKMEKA	EDKKTALPAG	LSATEKADAH
250	260	270	280	290	300
EEDELRAAEE	QRIQSLMTKM	TAMANEESRL	TASSVGQIVG	LCSAEIKQIV	SEYAEKQSEL
310	320	330	340	350	360
SAEESPEKLG	TSQLHRRKVI	SLNKQIAQKT	KHLEELRASH	TSLQARYNEA	KKTLTELKTY
370	380	390	400	410	420
SEKLDKEQAA	LEKIESKADP	SILQNLRALV	AMNENLKSQE	QEFKAHCREE	MTRLQQEIEN
430	440	450	460	470	480
LKAERAPRGD	EKTLSSGEPP	GTLTSAMTHD	EDLDRRYNME	KEKLYKIRLL	QARRNREIAI
490	500	510	520	530	540
LHRKIDEVPS	RAELIQYQKR	FIELYRQISA	VHKETKQFFT	LYNTLDDKKV	YLEKEISLLN
550	560	570	580	590	600
SIHENFSQAM	ASPAARDQFL	RQMEQIVEGI	KQSRMKMEKK	KQENKMRRDQ	LNDQYLELLE
610	620	630
KQRLYFKTVK	EFKEEGRKNE	MLLSKVKAKA	S