Q56648
Gene name |
alaS |
Protein name |
Alanine--tRNA ligase |
Names |
Alanyl-tRNA synthetase, AlaRS |
Species |
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) |
KEGG Pathway |
vch:VC_0545 |
EC number |
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q56648
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q56648-F1 | Predicted | AlphaFoldDB |
No variants for Q56648
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q56648 | |||||
No associated diseases with Q56648
4 regional properties for Q56648
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.7 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| alanine-tRNA ligase activity | Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). |
| amino acid binding | Binding to an amino acid, organic acids containing one or more amino substituents. |
| aminoacyl-tRNA editing activity | The hydrolysis of an incorrectly aminoacylated tRNA. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| tRNA binding | Binding to a transfer RNA. |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| alanyl-tRNA aminoacylation | The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| tRNA modification | The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFMSTDEVRR | AFLSFFESKG | HQIVESSSLV | PANDPTLLFT | NAGMNQFKDC | FLGLEKRAYT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RATTAQRCVR | AGGKHNDLEN | VGFTARHHTF | FEMLGNFSFG | DYFKEDAIQY | AWEFLTDVLQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPKERLLVTV | YETDDEAFDI | WNKKVGIPAD | RIIRIGDKKG | GKKFDSDNFW | QMGDTGPCGP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CTEIFYDHGD | HIWGGPPGSP | EEDGDRFIEI | WNNVFMQFNR | HADGTMEPLP | KPSVDTGMGI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ERISAIMQGV | HSNYEIDVFQ | TLIKAAADAI | GYQDLTNQSL | RVVADHIRSC | AFLIVDGVMP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SNEGRGYVLR | RIIRRAVRHG | NKLGAQGAFF | HKLVGPLAEV | MGTAGVELKK | QQALVEKVLR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IEEENFGRTL | DRGMSILNDA | LDQLSGQVLD | GETVFKLYDT | YGFPADLTND | VARERGFSID |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EAGFEQAMEE | QRQRAREAGQ | FGTDYNSLIK | SATNTEFCGY | TASRGQSVVR | EMFVEGAEVS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TLSAGDKAII | VLDNTPFYAE | SGGQCGDTGV | LKTDAGIFHV | EDTQKLGNAI | AHHGVIAQGV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LATGDQVDAI | VDEKRRAAIS | LNHSATHLLH | AALRKVLGEH | VAQKGSLVRA | ETLRFDFSHL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EAMTAAEIKE | VERLVNQEVR | RNHSIETNIM | NIDEAKAKGA | MALFGEKYDD | QVRVLSMGDF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| STELCGGIHA | SNTGDIGLFK | IISEGGIAAG | IRRIEAVTGE | GALDYLDAQQ | AQHDAKVSEM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AAKAKLLEKE | IQQLKDKLAA | KESAGLINQV | KQIAGVNVLV | AQLNGADNKA | LRGMVDDLKN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QLSSGIIMLG | NVAEGKVGLI | AGVTNDLTNK | VKAGELVNMV | ALQVGGKGGG | RPDMAQAGGT |
| 850 | |||||
| DAHALPSALE | SVDAWIAERL |