Q56366

PR
Gene name
pol (polA)
Protein name
DNA polymerase
Names
Species
Thermococcus sp (strain 9oN-7)
KEGG Pathway
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

338-412 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

10 structures for Q56366

Entry ID Method Resolution Chain Position Source
1QHT X-ray 210 A A 1-775 PDB
4K8X X-ray 228 A A 1-775 PDB
5OMQ X-ray 220 A A 1-775 PDB
5OMV X-ray 200 A A 1-775 PDB
6IS7 X-ray 280 A A/B 1-775 PDB
6ISF X-ray 280 A A/B 1-775 PDB
6ISG X-ray 340 A A 1-775 PDB
6ISH X-ray 330 A A 1-775 PDB
6ISI X-ray 320 A A 1-775 PDB
AF-Q56366-F1 Predicted AlphaFoldDB

No variants for Q56366

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q56366

No associated diseases with Q56366

4 regional properties for Q56366

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family B, exonuclease domain 22 - 129 IPR006133-1
domain DNA-directed DNA polymerase, family B, exonuclease domain 130 - 278 IPR006133-2
domain DNA-directed DNA polymerase, family B, multifunctional domain 352 - 747 IPR006134
conserved_site DNA-directed DNA polymerase, family B, conserved site 538 - 546 IPR017964

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MILDTDYITE NGKPVIRVFK KENGEFKIEY DRTFEPYFYA LLKDDSAIED VKKVTAKRHG
70 80 90 100 110 120
TVVKVKRAEK VQKKFLGRPI EVWKLYFNHP QDVPAIRDRI RAHPAVVDIY EYDIPFAKRY
130 140 150 160 170 180
LIDKGLIPME GDEELTMLAF DIETLYHEGE EFGTGPILMI SYADGSEARV ITWKKIDLPY
190 200 210 220 230 240
VDVVSTEKEM IKRFLRVVRE KDPDVLITYN GDNFDFAYLK KRCEELGIKF TLGRDGSEPK
250 260 270 280 290 300
IQRMGDRFAV EVKGRIHFDL YPVIRRTINL PTYTLEAVYE AVFGKPKEKV YAEEIAQAWE
310 320 330 340 350 360
SGEGLERVAR YSMEDAKVTY ELGREFFPME AQLSRLIGQS LWDVSRSSTG NLVEWFLLRK
370 380 390 400 410 420
AYKRNELAPN KPDERELARR RGGYAGGYVK EPERGLWDNI VYLDFRSLYP SIIITHNVSP
430 440 450 460 470 480
DTLNREGCKE YDVAPEVGHK FCKDFPGFIP SLLGDLLEER QKIKRKMKAT VDPLEKKLLD
490 500 510 520 530 540
YRQRAIKILA NSFYGYYGYA KARWYCKECA ESVTAWGREY IEMVIRELEE KFGFKVLYAD
550 560 570 580 590 600
TDGLHATIPG ADAETVKKKA KEFLKYINPK LPGLLELEYE GFYVRGFFVT KKKYAVIDEE
610 620 630 640 650 660
GKITTRGLEI VRRDWSEIAK ETQARVLEAI LKHGDVEEAV RIVKEVTEKL SKYEVPPEKL
670 680 690 700 710 720
VIHEQITRDL RDYKATGPHV AVAKRLAARG VKIRPGTVIS YIVLKGSGRI GDRAIPADEF
730 740 750 760 770
DPTKHRYDAE YYIENQVLPA VERILKAFGY RKEDLRYQKT KQVGLGAWLK VKGKK