Q56319

PR
Gene name
trpC (TM_0140)
Protein name
Indole-3-glycerol phosphate synthase
Names
IGPS
Species
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
KEGG Pathway
tma:TM0140
EC number
4.1.1.48: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q56319

Entry ID Method Resolution Chain Position Source
1I4N X-ray 250 A A/B 2-252 PDB
1J5T X-ray 300 A A 24-252 PDB
AF-Q56319-F1 Predicted AlphaFoldDB

No variants for Q56319

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q56319

No associated diseases with Q56319

2 regional properties for Q56319

Type Name Position InterPro Accession
conserved_site Indole-3-glycerol phosphate synthase, conserved site 44 - 58 IPR001468
domain Indole-3-glycerol phosphate synthase domain 2 - 249 IPR013798

Functions

Description
EC Number 4.1.1.48 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
indole-3-glycerol-phosphate synthase activity Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O.
phosphoribosylanthranilate isomerase activity Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

1 GO annotations of biological process

Name Definition
tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRRLWEIVEA KKKDILEIDG ENLIVQRRNH RFLEVLSGKE RVKIIAEFKK ASPSAGDINA
70 80 90 100 110 120
DASLEDFIRM YDELADAISI LTEKHYFKGD PAFVRAARNL TCRPILAKDF YIDTVQVKLA
130 140 150 160 170 180
SSVGADAILI IARILTAEQI KEIYEAAEEL GMDSLVEVHS REDLEKVFSV IRPKIIGINT
190 200 210 220 230 240
RDLDTFEIKK NVLWELLPLV PDDTVVVAES GIKDPRELKD LRGKVNAVLV GTSIMKAENP
250
RRFLEEMRAW SE