Q56310

PR
Gene name
cheA (TM_0702)
Protein name
Chemotaxis protein CheA
Names
Species
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
KEGG Pathway
tma:TM0702
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

89-179 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

17 structures for Q56310

Entry ID Method Resolution Chain Position Source
1B3Q X-ray 260 A A/B 293-671 PDB
1I58 X-ray 160 A A/B 352-540 PDB
1I59 X-ray 180 A A/B 352-540 PDB
1I5A X-ray 190 A A/B 352-540 PDB
1I5B X-ray 194 A A/B 352-540 PDB
1I5C X-ray 190 A A/B 352-540 PDB
1I5D X-ray 290 A A 350-540 PDB
1TQG X-ray 098 A A 4-104 PDB
1U0S X-ray 190 A A 175-260 PDB
2CH4 X-ray 350 A A/B 355-671 PDB
2LD6 NMR - A 1-131 PDB
3JA6 EM 1270 A C/E 293-671 PDB
3UR1 X-ray 450 A A 355-671 PDB
4JPB X-ray 319 A A 355-671 PDB
4XIV X-ray 300 A A/B 289-540 PDB
6MI6 X-ray 295 A A/B/C/D 353-539 PDB
AF-Q56310-F1 Predicted AlphaFoldDB

No variants for Q56310

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q56310

No associated diseases with Q56310

10 regional properties for Q56310

Type Name Position InterPro Accession
domain CheW-like domain 533 - 671 IPR002545
domain Histidine kinase/HSP90-like ATPase 398 - 541 IPR003594
domain Histidine kinase CheA-like, homodimeric domain 293 - 353 IPR004105
domain Signal transduction histidine kinase-related protein, C-terminal 443 - 457 IPR004358-1
domain Signal transduction histidine kinase-related protein, C-terminal 485 - 495 IPR004358-2
domain Signal transduction histidine kinase-related protein, C-terminal 501 - 519 IPR004358-3
domain Signal transduction histidine kinase-related protein, C-terminal 525 - 538 IPR004358-4
domain Histidine kinase domain 291 - 541 IPR005467
domain Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1 - 102 IPR008207
domain Chemotaxis protein CheA, P2 response regulator-binding 179 - 259 IPR010808

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
protein domain specific binding Binding to a specific domain of a protein.

1 GO annotations of biological process

Name Definition
chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMEEYLGVFV DETKEYLQNL NDTLLELEKN PEDMELINEA FRALHTLKGM AGTMGFSSMA
70 80 90 100 110 120
KLCHTLENIL DKARNSEIKI TSDLLDKIFA GVDMITRMVD KIVSEGSDDI GENIDVFSDT
130 140 150 160 170 180
IKSFASSGKE KPSEIKNETE TKGEEEHKGE STSNEEVVVL PEEVAHVLQE ARNKGFKTFY
190 200 210 220 230 240
IKVILKEGTQ LKSARIYLVF HKLEELKCEV VRTIPSVEEI EEEKFENEVE LFVISPVDLE
250 260 270 280 290 300
KLSEALSSIA DIERVIIKEV TAVTEESGAE KRTEKEEKTE KTEEKAERKK VISQTVRVDI
310 320 330 340 350 360
EKLDNLMDLM GELVIARSRI LETLKKYNIK ELDESLSHLS RITLDLQNVV MKIRMVPISF
370 380 390 400 410 420
VFNRFPRMVR DLAKKMNKEV NFIMRGEDTE LDRTFVEEIG EPLLHLLRNA IDHGIEPKEE
430 440 450 460 470 480
RIAKGKPPIG TLILSARHEG NNVVIEVEDD GRGIDKEKII RKAIEKGLID ESKAATLSDQ
490 500 510 520 530 540
EILNFLFVPG FSTKEKVSEV SGRGVGMDVV KNVVESLNGS ISIESEKDKG TKVTIRLPLT
550 560 570 580 590 600
LAIIQALLVK VNNLVYAIPI ANIDTILSIS KEDIQRVQDR DVIVIRGEVI PVYRLWEVLQ
610 620 630 640 650 660
IEHKEELEEM EAVIVRVGNR KYGIVVDDLL GQDDIVIKSL GKVFSEVKEF SGAAILGDGS
670
IALIINVSGI V