Q562C4

PR
Gene name
Mettl7b
Protein name
Thiol S-methyltransferase METTL7B
Names
Associated with lipid droplet protein 1, ALDI, Methyltransferase-like protein 7B
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:366792
EC number
2.1.1.9: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

19-95 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q562C4

Entry ID Method Resolution Chain Position Source
AF-Q562C4-F1 Predicted AlphaFoldDB

No variants for Q562C4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q562C4

No associated diseases with Q562C4

1 regional properties for Q562C4

Type Name Position InterPro Accession
domain Methyltransferase type 11 75 - 172 IPR013216

Functions

Description
EC Number 2.1.1.9 Methyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Peripheral membrane protein
  • Lipid droplet
  • Microsome
  • Cytoplasm, cytosol
  • Highly concentrated in the perinuclear area of the endoplasmic reticulum (ER) and surrounding lipid droplets
  • May be associated with the specific regions of the LR that form lipid droplets and targeted to the initial deposits of lipids where the lipid droplets form
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

3 GO annotations of molecular function

Name Definition
methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
S-adenosylmethionine-dependent methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
thiol S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether.

1 GO annotations of biological process

Name Definition
methylation The process in which a methyl group is covalently attached to a molecule.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H8H3 METTL7A Putative methyltransferase-like protein 7A Homo sapiens (Human) PR
10 20 30 40 50 60
MDVLVPLLQL LVLLLTLPLH LLALLGCWQP ICKTYFPYLM ATLTARSYKK MESKKRELFS
70 80 90 100 110 120
QIKDLKGTSN EVTLLELGCG TGANFQFYPP GCKVTCVDPN PNFEKFLTKS MAENRHLQYE
130 140 150 160 170 180
RFIVAYGENM KQLADSSMDV VVCTLVLCSV QSPRKVLQEV QRVLKPGGLL FFWEHVSEPQ
190 200 210 220 230 240
GSQALLWQRV LEPTWKHIGD GCHLTRETWK DIEKAQFSEV QLEWQPPPFK WLPVGPHIMG
KAVK