Q55GV3

PR
Gene name
pakC (DDB_G0267450)
Protein name
Serine/threonine-protein kinase pakC
Names
dPAKc
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0267450
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

343-366 (Activation loop from InterPro)

Target domain

204-458 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q55GV3

Entry ID Method Resolution Chain Position Source
AF-Q55GV3-F1 Predicted AlphaFoldDB

No variants for Q55GV3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q55GV3

No associated diseases with Q55GV3

10 regional properties for Q55GV3

Type Name Position InterPro Accession
repeat WD40 repeat 97 - 262 IPR001680-1
repeat WD40 repeat 265 - 410 IPR001680-2
domain LIS1 homology motif 7 - 39 IPR006594
conserved_site WD40 repeat, conserved site 165 - 179 IPR019775-1
conserved_site WD40 repeat, conserved site 207 - 221 IPR019775-2
conserved_site WD40 repeat, conserved site 311 - 325 IPR019775-3
conserved_site WD40 repeat, conserved site 395 - 409 IPR019775-4
repeat G-protein beta WD-40 repeat 123 - 137 IPR020472-1
repeat G-protein beta WD-40 repeat 207 - 221 IPR020472-2
repeat G-protein beta WD-40 repeat 311 - 325 IPR020472-3

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Membrane
  • Cytosolic in unstimulated cells, localizes to the plasma membrane in response to chemoattractant stimulation with kinetics consistent with those of kinase activation, where it binds to phospholipids via its PH domain
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
phosphatidylinositol-3,4-bisphosphate binding Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
small GTPase binding Binding to a small monomeric GTPase.

7 GO annotations of biological process

Name Definition
chemotaxis to cAMP The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP.
establishment or maintenance of cell polarity Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
mitotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
negative regulation of pseudopodium assembly Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of MAPK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MISLDLSPTL WKSPDKEGEL KKQGHVVKNW KKRKFIIQND MLFYFKDKEE RPVGAVPLRM
70 80 90 100 110 120
SRCYENKSLG KPNCFELVSP RINKTFFIQA NTPDEMASWM KAVEKGSEYS TVSQPFNLKH
130 140 150 160 170 180
EVHVDFNSAT GFSGLPKEWE VILKSSNVSK QEVLDKPSEW LSVLEFQAGR TMEKSNSQNL
190 200 210 220 230 240
SALPDESNLT LSDLVTKEDP TKIYKNMTKI GEGAAGEVFV ATSSKNNKRV AIKKIEINND
250 260 270 280 290 300
NAKLLVTEIA IMKTSHHDNI VNYIDSYIVN DRELWVAMEF MGGGCLTDIL EAFDNIKMSE
310 320 330 340 350 360
IQIAYVVKET LKALQYIHSL HRIHRDIKSD NILLGSEGSV KIADFGYAAQ LTQKQQKRNT
370 380 390 400 410 420
VVGTPYWMAP ELIRGHDYGV KVDIWSLGIM MMEMAEGEPP YMDFPPLRAL FLITTKGIPP
430 440 450 460 470
LKETTKWSKT FQDFFSKCLD INVANRPDAT DLLKHPFMDL ACDSSEFKPL IQAARNV