Q55E54

PR
Gene name
corB (cor7, DDB_G0269388)
Protein name
Coronin-B
Names
Coronin-7, DdCRN7, Doublecoronin
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0269388
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

878-962 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q55E54

Entry ID Method Resolution Chain Position Source
AF-Q55E54-F1 Predicted AlphaFoldDB

No variants for Q55E54

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q55E54

No associated diseases with Q55E54

15 regional properties for Q55E54

Type Name Position InterPro Accession
repeat WD40 repeat 65 - 107 IPR001680-1
repeat WD40 repeat 117 - 199 IPR001680-2
repeat WD40 repeat 202 - 246 IPR001680-3
repeat WD40 repeat 250 - 291 IPR001680-4
repeat WD40 repeat 552 - 588 IPR001680-5
repeat WD40 repeat 605 - 649 IPR001680-6
repeat WD40 repeat 651 - 690 IPR001680-7
domain Domain of unknown function DUF1899 1 - 64 IPR015048-1
domain Domain of unknown function DUF1899 486 - 549 IPR015048-2
conserved_site WD40 repeat, conserved site 92 - 106 IPR019775-1
conserved_site WD40 repeat, conserved site 144 - 158 IPR019775-2
conserved_site WD40 repeat, conserved site 632 - 646 IPR019775-3
repeat G-protein beta WD-40 repeat 92 - 106 IPR020472-1
repeat G-protein beta WD-40 repeat 144 - 158 IPR020472-2
repeat G-protein beta WD-40 repeat 632 - 646 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell projection
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cell cortex
  • Accumulates in cell surface projections during movement, phagocytosis and pinocytosis
  • Detected at the leading edge of the cell during chemotaxis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell leading edge The area of a motile cell closest to the direction of movement.
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
cortical actin cytoskeleton The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
phagocytic cup An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.

1 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

8 GO annotations of biological process

Name Definition
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
ameboidal-type cell migration Cell migration that is accomplished by extension and retraction of a pseudopodium.
cell-substrate adhesion The attachment of a cell to the underlying substrate via adhesion molecules.
cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
lateral pseudopodium retraction The myosin-based contraction and retraction of a lateral pseudopodium.
negative regulation of actin filament depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.
phagocytosis A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFKVSKYRHT VGKIDKRELW YPDVNTTGNS SASTFIKANS KWVALNWQSN TGTIGLIPLK
70 80 90 100 110 120
SFGKRKGETF LIHAHSSGVI DFEFNPFNEH QLVTASDDST IKVWNIDEAI RSGATSLSSA
130 140 150 160 170 180
SIVCSGHSKS VECIAFNPVA NNILASCSAD KTLKIWDLSN GEEKYSWNFE QGSLTSLSWN
190 200 210 220 230 240
YDGSLLVATG KDLKNRIIDA RTGESIQVGD GNQGVKASRV VWLGNLNHFL TAGFSKMRER
250 260 270 280 290 300
QLVLWSSQDL SKPIKSITLD SSTGIISPIY DQDAQLLFIS GSGDSSVRVF DMNTQFTKDP
310 320 330 340 350 360
AFTELSPVPS DTPSKGICAL PKRALDVMEV EIDRIFKATP NNIIPITFNM SRKSKSTFAD
370 380 390 400 410 420
DLFPNTASTK PSLSSIDWLS GENKQPILVS LNPSDNQINN DLDDLQLNDN EPVKKSTFFI
430 440 450 460 470 480
DDNTNDNSNV VEQSKSEPEQ QQQEEKKISS SSSSSSPTNS SSNVINSTPS SPIVNDNIQR
490 500 510 520 530 540
TGIVPKVVRS SKYRHISGSA HQKSQFYTNL KINGSTSNTC IAVNSEYVAV PMVGIGGPLA
550 560 570 580 590 600
VIPLADKGRQ IQVPCIEIGS QLCDYDLSQH NTSLVATGSE DSHVKVFKIP TGGIPKTTAN
610 620 630 640 650 660
KSNNYTTTEA DFVGHNRKVI SVNFHPTAEN VLITSGGDMV VKLWDLNEGG AGEKLSFANV
670 680 690 700 710 720
HTDMITSVDV NWTGDKILTS SKDKKMRIFD PRTNKGGLAS ETVTHSGSKG GKAVWLGQTG
730 740 750 760 770 780
NIFSVGFNKS SEREYQLWDS RNLQSGTPLA SDKLDHLSGV ITPFYDEDSG VIYLAGKGDS
790 800 810 820 830 840
SIRMFEINDQ EPYVHYLTQF SAGTPQVGVA KFAKKTSMDV KKCEIARFYR STDSTIEPLS
850 860 870 880 890 900
MTVPRNRQEF FQDDIYPDTR QTCTPVMTSE EWFDGCIREP EFVSMKPSDM INLSDAPPPP
910 920 930 940 950 960
KKEDKFVVSQ EVDNTPSRDQ VTNSLLSRVS NQNASSNWEQ IEKLKHNFTD YDNGDISDSE
WD