Q55D85

PR
Gene name
cas1 (DDB_G0269226)
Protein name
Cycloartenol synthase
Names
2,3-epoxysqualene--cycloartenol cyclase, Oxidosqualene cyclase
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0269226
EC number
5.4.99.8: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q55D85

Entry ID Method Resolution Chain Position Source
AF-Q55D85-F1 Predicted AlphaFoldDB

No variants for Q55D85

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q55D85

No associated diseases with Q55D85

3 regional properties for Q55D85

Type Name Position InterPro Accession
conserved_site Terpene synthase, conserved site 553 - 567 IPR002365
domain Squalene cyclase, C-terminal 366 - 695 IPR032696
domain Squalene cyclase, N-terminal 59 - 352 IPR032697

Functions

Description
EC Number 5.4.99.8 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.

2 GO annotations of molecular function

Name Definition
cycloartenol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol.
lanosterol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.

3 GO annotations of biological process

Name Definition
cholesterol biosynthetic process The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
sterol biosynthetic process The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
triterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTTNWSLKV DRGRQTWEYS QEKKEATDVD IHLLRLKEPG THCPEGCDLN RAKTPQQAIK
70 80 90 100 110 120
KAFQYFSKVQ TEDGHWAGDY GGPMFLLPGL VITCYVTGYQ LPESTQREII RYLFNRQNPV
130 140 150 160 170 180
DGGWGLHIEA HSDIFGTTLQ YVSLRLLGVP ADHPSVVKAR TFLLQNGGAT GIPSWGKFWL
190 200 210 220 230 240
ATLNAYDWNG LNPIPIEFWL LPYNLPIAPG RWWCHCRMVY LPMSYIYAKK TTGPLTDLVK
250 260 270 280 290 300
DLRREIYCQE YEKINWSEQR NNISKLDMYY EHTSLLNVIN GSLNAYEKVH SKWLRDKAID
310 320 330 340 350 360
YTFDHIRYED EQTKYIDIGP VNKTVNMLCV WDREGKSPAF YKHADRLKDY LWLSFDGMKM
370 380 390 400 410 420
QGYNGSQLWD TAFTIQAFME SGIANQFQDC MKLAGHYLDI SQVPEDARDM KHYHRHYSKG
430 440 450 460 470 480
AWPFSTVDHG WPISDCTAEG IKSALALRSL PFIEPISLDR IADGINVLLT LQNGDGGWAS
490 500 510 520 530 540
YENTRGPKWL EKFNPSEVFQ NIMIDYSYVE CSAACIQAMS AFRKHAPNHP RIKEINRSIA
550 560 570 580 590 600
RGVKFIKSIQ RQDGSWLGSW GICFTYGTWF GIEGLVASGE PLTSPSIVKA CKFLASKQRA
610 620 630 640 650 660
DGGWGESFKS NVTKEYVQHE TSQVVNTGWA LLSLMSAKYP DRECIERGIK FLIQRQYPNG
670 680 690 700
DFPQESIIGV FNFNCMISYS NYKNIFPLWA LSRYNQLYLK SKI