Q55BR6

PR
Gene name
orcC (orc3, DDB_G0271078)
Protein name
Origin recognition complex subunit 3
Names
Origin replication complex subunit C
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0271078
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

528-717 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q55BR6

Entry ID Method Resolution Chain Position Source
AF-Q55BR6-F1 Predicted AlphaFoldDB

No variants for Q55BR6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q55BR6

No associated diseases with Q55BR6

2 regional properties for Q55BR6

Type Name Position InterPro Accession
domain Origin recognition complex subunit 3, winged helix C-terminal 980 - 1038 IPR040855
domain Origin recognition complex subunit 3, N-terminal 194 - 542 IPR045667

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
DNA replication preinitiation complex A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.
nuclear origin of replication recognition complex A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.
nuclear pre-replicative complex A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.

1 GO annotations of molecular function

Name Definition
DNA replication origin binding Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.

1 GO annotations of biological process

Name Definition
DNA replication initiation The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGENYCSVC EGIISTENDL AVCYKCKEEI FHKACGKKVF DSLRCLNCGP IEKRSLSHQI
70 80 90 100 110 120
GEISKGKAKL ETRTSRFTGI NVTKEFIESG EYGISKGDDD DDGDYVGGDD SSSDDEYFGN
130 140 150 160 170 180
PTVLNNYPTT MNNVDLNFPT FFLLNEDMKK RKQKIKEDGN NEEIKKIEQE EKMIIQEYQN
190 200 210 220 230 240
EEILKFFGDR SCFKQTQLAY EAMVQCLKDL KESIERMFKV VSVKTLGDIS SFISMSYPKK
250 260 270 280 290 300
SLLDIRDIAL ELIGQSIDDS IHHIPTSILY TSSSSPEVAQ LFQSVPSNVM MRIKSHQPFS
310 320 330 340 350 360
SDISSHLCEP PTITLNPDCC NTFKSTVSTI CHSLTKDYDV TKFPSPHFED LSRWYSNYFS
370 380 390 400 410 420
IPLIQEVIEL FKQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QKDKLEEIML VRTPVILVIE
430 440 450 460 470 480
DFETWNSEVL SDLIHLLSAY RHRIPFVLSF SISTSADAIH KVLPYQVVSL LNLKSLHLRS
490 500 510 520 530 540
QNEMFEQLVK HLFLKSQPYI ISKKAYLYLY YNFKNSYMSL STTISVLRHF IIDHFLENGL
550 560 570 580 590 600
SYLTLDLSNF QIDLKDDDDD MDGCSTIKLE PENDSTDSTV NDEVGTGDNI DNDNVSTHGE
610 620 630 640 650 660
EDTPDSLVKS DIECQTLSYS SDDERNDYDT STDSDNCSNF HKKKPNSNNR IKSDLECNDN
670 680 690 700 710 720
DKDNDDNDND INENNNNINN NNNNNSNNDD NDKDSFGPKR IPNQRFVTLI QKLPSLNTDE
730 740 750 760 770 780
IENSKISTNR KLNKLQSNLI IFKESRPIML ELYYTILSKF QKSKTLKYSE LLKKISLNDR
790 800 810 820 830 840
KSYETLRKTI LTNPESKQSI ETLLDLLKTS RHHFERIIKA TNSLKLFQTP KSKKYQDLVK
850 860 870 880 890 900
IENLILKCRT LSNNFKNLLL PPDEQSKSIK NEIKQQQQQQ QQQQQQQQQQ QHQQQQKIEN
910 920 930 940 950 960
EQKNWSIKKK REHQLRNIQK PTDSYFKIYS REFLDDIVSV IIEDYLYPPL VSVPLSEIFD
970 980 990 1000 1010 1020
FTQTVFITQS RFNFHTAEGI NDNLIHSVRK LKCECCIDSL CGTMDDFSIS FILLLRSGRY
1030 1040 1050 1060 1070
INYFDWLTSF CSIINGDNNP TPNLKARFIK SVDTFVSLEL IKKTRKRKDH FEKIAFLTTS