Q55BK0
Gene name |
ufd1 (DDB_G0271122) |
Protein name |
Ubiquitin fusion degradation protein 1 homolog |
Names |
|
Species |
Dictyostelium discoideum (Slime mold) |
KEGG Pathway |
ddi:DDB_G0271122 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q55BK0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q55BK0-F1 | Predicted | AlphaFoldDB |
No variants for Q55BK0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q55BK0 | |||||
No associated diseases with Q55BK0
No regional properties for Q55BK0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q55BK0 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| VCP-NPL4-UFD1 AAA ATPase complex | A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry). |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| polyubiquitin modification-dependent protein binding | Binding to a protein upon poly-ubiquitination of the target protein. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| ER-associated misfolded protein catabolic process | The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNLDEYVRSL | RGEVMGHHHG | GPGRYEQKFK | AFPISFLPKE | KHSLESGGKI | LLPPSALNAL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SRLNIQYPML | FEISNPISGK | KSHCGVLEFI | AEEGICYLPL | WMMQNLQLKE | GEFIDIKNAT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LAKGTFVKIQ | PRTSNFIDIS | NPKAVLENSL | RKFATLTKDD | EIMIDYNNTK | YYLKVVELKP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ANAISIIEAD | VSVDFAPPMD | SKEATSPSTS | SPGSHVSGPS | KGLTFGPAST | SAKPIPGGKK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KKDESDSDSD | SDDEPKFKAF | AGTGARLDGK | VGTPLGTSPK | TLNTNNNNNN | NNNNNNNNNN |
| 310 | 320 | ||||
| NNNNNSNNNN | TKNEDTKFKS | FSGKGHSLKD |