Q559R0

PR
Gene name
sarA (DDB_G0272296)
Protein name
GTP-binding protein Sar1A
Names
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0272296
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

74-147 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q559R0

Entry ID Method Resolution Chain Position Source
AF-Q559R0-F1 Predicted AlphaFoldDB

No variants for Q559R0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q559R0

No associated diseases with Q559R0

11 regional properties for Q559R0

Type Name Position InterPro Accession
domain RNA recognition motif domain 688 - 766 IPR000504-1
domain RNA recognition motif domain 785 - 862 IPR000504-2
repeat HAT (Half-A-TPR) repeat 88 - 120 IPR003107-1
repeat HAT (Half-A-TPR) repeat 126 - 157 IPR003107-2
repeat HAT (Half-A-TPR) repeat 163 - 199 IPR003107-3
repeat HAT (Half-A-TPR) repeat 304 - 336 IPR003107-4
repeat HAT (Half-A-TPR) repeat 339 - 371 IPR003107-5
repeat HAT (Half-A-TPR) repeat 374 - 410 IPR003107-6
repeat HAT (Half-A-TPR) repeat 467 - 500 IPR003107-7
domain SART3, RNA recognition motif 1 689 - 762 IPR034217
domain SART3, RNA recognition motif 2 783 - 863 IPR034218

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Peripheral membrane protein
  • Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein
  • Cytoplasm, cytosol
  • Active at endoplasmic reticulum exit sites (ERES) where it inserts into the membrane and recruits the remainder of the coat protein complex II/COPII
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.
endoplasmic reticulum exit site An endoplasmic reticulum part at which COPII-coated vesicles are produced.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

6 GO annotations of biological process

Name Definition
endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
positive regulation of protein exit from endoplasmic reticulum Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum.
regulation of COPII vesicle coating Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.
vesicle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFLFDWFWNV LSFLGLYNKN AKILFLGLDN AGKTTLLGVL KDGRLSSYLP TFHPTSEELA
70 80 90 100 110 120
MGNIRFKAFD LGGHESARRL WKDYYPSVDA IVYLIDSSAQ DRFVESKKEL DSLLSSDELA
130 140 150 160 170 180
NVPFLILGNK VDIGNTSEEK FRASLGLTQT TGKGKTTLNG VRPIEVFMCS VVKRYGYAEG
FRWLANYL