Q557J3

PR
Gene name
polr3h-1 (rpc25, rpc8, DDB_G0273425;, polr3h-2, rpc25, rpc8, DDB_G0273523)
Protein name
DNA-directed RNA polymerase III subunit rpc8
Names
RNA polymerase III subunit C8, DNA-directed RNA polymerase III subunit H
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0273523
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

123-252 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q557J3

Entry ID Method Resolution Chain Position Source
AF-Q557J3-F1 Predicted AlphaFoldDB

No variants for Q557J3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q557J3

No associated diseases with Q557J3

2 regional properties for Q557J3

Type Name Position InterPro Accession
domain RNA polymerase Rpb7-like, N-terminal 8 - 63 IPR005576
domain RNA polymerase III, subunit Rpc25 82 - 214 IPR013238

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
RNA polymerase III complex RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

1 GO annotations of molecular function

Name Definition
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.

1 GO annotations of biological process

Name Definition
transcription initiation at RNA polymerase III promoter A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFHLITIEDK VRIAPSQFNN EVQTIEDEIE KKYTSKVVLN AGLFVALYDI LGTGDSYVHS
70 80 90 100 110 120
GDGGAHLMVR FRMVVFKPFK GEVLEGVIKK SSRQSIQISL GFFHEIYLNP IELPNPSNYN
130 140 150 160 170 180
QEEGLWYWEW NENQLFFEDG GRVRFKIDQV EFNPEISQPA PSPKNVNTEA MDSYSLREYK
190 200 210 220 230 240
EKQIENENLL KQVKSPLILK VSMREAGLGM VSWWTNQSAG DDDENEEDGG ENQDDEVAED
250
DGGEEPTIEE DE