Q557D2

PR
Gene name
g6pd-1 (zwf, DDB_G0273131;, g6pd-2, zwf, DDB_G0273639)
Protein name
Glucose-6-phosphate 1-dehydrogenase
Names
G6PD
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0273639
EC number
1.1.1.49: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

222-338 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q557D2

Entry ID Method Resolution Chain Position Source
AF-Q557D2-F1 Predicted AlphaFoldDB

No variants for Q557D2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q557D2

No associated diseases with Q557D2

5 regional properties for Q557D2

Type Name Position InterPro Accession
conserved_site GHMP kinase, ATP-binding, conserved site 125 - 136 IPR006203
domain GHMP kinase N-terminal domain 118 - 185 IPR006204
domain GHMP kinase, C-terminal domain 290 - 370 IPR013750
domain Galactokinase, N-terminal domain 13 - 61 IPR019539
conserved_site Galactokinase, conserved site 30 - 41 IPR019741

Functions

Description
EC Number 1.1.1.49 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.

2 GO annotations of molecular function

Name Definition
glucose-6-phosphate dehydrogenase activity Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

2 GO annotations of biological process

Name Definition
glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
pentose-phosphate shunt, oxidative branch The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSTPDSRSV LTVIILGASG DLAKKKTYPA LFGLYLRDLL PSNTIIYGYA RSHIEIGDFK
70 80 90 100 110 120
ARISKGLKGD EEKKKQFLNL LHYHSGKYDE KASYDEFEKL ILAEEKKQQG VDKFNRLFYM
130 140 150 160 170 180
AIPPSIFIEV SIGIHGSLIS KNGWSRVIVE KPFGRDLASS RELVSELGKL FKEKDLFRID
190 200 210 220 230 240
HYLGKEMVQN LMVLRFANAV FEPLWSKSHI SSITITFKED IGTEGRGGYF DQFGIIRDVM
250 260 270 280 290 300
QNHLLQVLSL VAMEPPVSLN ADDITNEKVK LLRCIQPIKM SEVVLGQYTS DPEGKIPAYL
310 320 330 340 350 360
DDEGVPKDST TPTYAAAVFH INNPRWRGMP FILKCGKALD ERKTEVRIQF KRPDNFLFSD
370 380 390 400 410 420
DDISRNELVM RIQPGEAVYL KLLSKKPGLE NKIEQTELDL SYRHRFENLD LPDAYERLIL
430 440 450 460 470 480
DSIKGDHNLF VRDDELDVAW QIFTPLLDQI EKEKIKPEPY SFGSRGPKSA DELSKKFGFI
490
RSLGYNWPGN SPQGSKK