Q556S2

PR
Gene name
pakH-2
Protein name
Serine/threonine-protein kinase pakH
Names
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0273865
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

180-202 (Activation loop from InterPro)

Target domain

42-294 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q556S2

Entry ID Method Resolution Chain Position Source
AF-Q556S2-F1 Predicted AlphaFoldDB

No variants for Q556S2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q556S2

No associated diseases with Q556S2

3 regional properties for Q556S2

Type Name Position InterPro Accession
domain Protein kinase domain 42 - 294 IPR000719
active_site Serine/threonine-protein kinase, active site 159 - 171 IPR008271
binding_site Protein kinase, ATP binding site 48 - 71 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of MAPK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVRLFRSGSN PKEIDISQPN SLVHKVHVDL DLNWSSGGET SFEIQEKLGE GSFGSVYRAI
70 80 90 100 110 120
HKSSNTSIAI KEFEIFEAND VEPISKEIQI LKKCNNPYVV SYFGSIMLKN KYWILMDYCS
130 140 150 160 170 180
LSSFNDIMQS IGKTFKEKEI SLILQQSLLG LVYLHSKQII HRDIKSANIL LDETGQVKIA
190 200 210 220 230 240
DFGVSQQIQS TFSKGSIAGT PYWMAPEILN QTDYNNKIDV WSLGIVAIEL ADGEPPLSEV
250 260 270 280 290 300
NPMRAMYMIG RRPPPTFKDP KKWSPEFVSF VDKCLTKDIN ERWSPSQLLD HPFIKSAKPD
310 320 330 340 350 360
ALKELTQMAI KLKSKKRKSI GPSVSPKQQP NDNNNNNNNN KPQFLSKLLN NNSNSSNDIG
370 380 390 400 410 420
ETTSGSVIYK PNVFSGSIDT GSVVIHNTIT SNNNDSGSVV LNSNTVINRS KPLPPPPSYE
430 440 450 460 470 480
SVILNDKLKQ QQQQQQQSNQ QTTTTTTKQN TIKNKFNTIS NTIKCNTILV QDKTLEIIQK
490 500 510
TPMKNLDERN QKIVLYSTLG LILVLSVFFK FFK