Q554D9

PR
Gene name
asnS1 (DDB_G0275263)
Protein name
Asparagine--tRNA ligase, cytoplasmic
Names
Asparaginyl-tRNA synthetase, AsnRS
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0275263
EC number
6.1.1.22: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q554D9

Entry ID Method Resolution Chain Position Source
AF-Q554D9-F1 Predicted AlphaFoldDB

No variants for Q554D9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q554D9

No associated diseases with Q554D9

4 regional properties for Q554D9

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (D/K/N) 328 - 647 IPR004364
domain OB-fold nucleic acid binding domain, AA-tRNA synthetase-type 232 - 311 IPR004365
domain Aminoacyl-tRNA synthetase, class II 357 - 653 IPR006195
domain Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal 4 - 158 IPR007639

Functions

Description
EC Number 6.1.1.22 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.

3 GO annotations of molecular function

Name Definition
asparagine-tRNA ligase activity Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
nucleic acid binding Binding to a nucleic acid.

1 GO annotations of biological process

Name Definition
asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTEEDQKLF LSIGLDEKRA KDTLKNKDLT ALLKTIIEEA SVSKGCDKSI GNLLYSLATC
70 80 90 100 110 120
QQVNSPIRSN VSKAIGEEKI KTTIQFQAAT QYLKDNKEFN QDTFNDFCGV GVVITPEQIQ
130 140 150 160 170 180
KAIDDLFTKK ATEISEKKWH IPIGDLLNPL KESLKWADLK EVKIMLDKKL ETTLGPKVVE
190 200 210 220 230 240
AKEKKVAATT TAPVKKIEEQ LAAITLKQDA SLPTPKRLKI RECSPKFANQ RVEVHAWAHH
250 260 270 280 290 300
VRNQKKIVFL ELRDGTGFLQ CVLSGDLVHP SIIDKLLREA TVKIVGTLVI PPADKKCPGG
310 320 330 340 350 360
VELQADYWEL LGPSNADLEG VINQESNVDH LFDQRHIMMR GTRASSIMKI RSLCLFAFRQ
370 380 390 400 410 420
HFFENHYMEV TPPTLVNTYC EGGSELFTVD YFGKPAYLTQ SSQLYLETML PVLGDNFTIT
430 440 450 460 470 480
QSYRAEKART RRHLTEFLHL EAECPFITYE ELQDRIEFLV VDVCEKLFKM DPELILSVNP
490 500 510 520 530 540
DFKVPKRPFM RMNYSDAIEY CKKNGIQKKL EDGTEVDFEF GDDIPEAQER RMNDQIGEPI
550 560 570 580 590 600
FLCRFPAEMK AFYMARCPED RTLTESLDLL MPGVGEIVGG SMRISDFNEL VAAYKKAGLD
610 620 630 640 650
TDEYYWFTDQ RKYGTTQHGG YGLGVERFLT WMLKEEHIRN VCVYQRTKDR ITP