Q553K4

PR
Gene name
nramp2 (mntH, DDB_G0275815)
Protein name
Natural resistance-associated macrophage protein 2 homolog
Names
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0275815
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

20-129 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q553K4

Entry ID Method Resolution Chain Position Source
AF-Q553K4-F1 Predicted AlphaFoldDB

No variants for Q553K4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q553K4

No associated diseases with Q553K4

5 regional properties for Q553K4

Type Name Position InterPro Accession
repeat Pumilio RNA-binding repeat 114 - 149 IPR001313-1
repeat Pumilio RNA-binding repeat 150 - 187 IPR001313-2
repeat Pumilio RNA-binding repeat 355 - 390 IPR001313-3
repeat Pumilio RNA-binding repeat 538 - 575 IPR001313-4
repeat Pumilio RNA-binding repeat 576 - 613 IPR001313-5

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
contractile vacuolar membrane The lipid bilayer surrounding the contractile vacuole.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
cadmium ion transmembrane transporter activity Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other.
ferrous iron transmembrane transporter activity Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other.
manganese ion transmembrane transporter activity Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.
symporter activity Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

7 GO annotations of biological process

Name Definition
aggregation involved in sorocarp development The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.
cellular manganese ion homeostasis Any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
iron ion export across plasma membrane The directed movement of iron ions from inside of a cell, across the plasma membrane and into the extracellular region.
iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
iron ion transport The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNNNNNNKKL NKENLNEIEN WNEIELTDYK KQGLDEGTSS NIYLFESNGN VVNGSIEDSP
70 80 90 100 110 120
KQQQQQQQQQ QQQQQQQQQQ QQQQQNIISS DEEIEDKPFQ DRDSNIGDGS DIDSSGDSID
130 140 150 160 170 180
IENTDYSILV PFEDEENNNG SKSKFSIKKL KSFLGPALFI SVGYMDPGNW ATDLEGGSRF
190 200 210 220 230 240
GYQLMWVLLF SNIMALFLQT LVIKLALVTK NDLAQQCRKE YSKTVNIFLW LILELAIIST
250 260 270 280 290 300
DLAEVIGTAI GLNILFGLPL IAGVAITSLD TLLFLAIQRW GIRKLELLIL LLLSMITMCF
310 320 330 340 350 360
VIELFLSKPI ASEVFSGFVP RLNSDSVMVA TGIVGATTMP HNLFLHGSVV KSRKIPNDRR
370 380 390 400 410 420
KSVIKQAYRY NVIDTVLALN CAFFVNIAIL MLAASVFWKS NIQVTELSEA YRLLTKLMDG
430 440 450 460 470 480
KLAAVLFGLG LFLAGQSSTI TGTMAGQIVM EGFIKLRIKP WLRRFITRLL AIIPAAIVII
490 500 510 520 530 540
VLGDKGTYTL LIISQVLLSI GLPFAVVPLI IFTSSYEIMG EFKNRLSIII INSIIALFII
550 560 570 580 590 600
GLNLATIFQL INDFLHNDSI ISKCLTIIFL IPLSIALCCL LLWLIISKIN FFTNLLSKIF
610 620
NNNNNNNNKN IINNNNNYSG NTINNQTIQ