Q54YW8

PR
Gene name
polr2h (rpb8, DDB_G0278039)
Protein name
DNA-directed RNA polymerases I, II, and III subunit rpabc3
Names
RNA polymerases I, II, and III subunit ABC3, RNA polymerase B subunit 8, RPB8, RPB17
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0278039
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

35-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54YW8

Entry ID Method Resolution Chain Position Source
AF-Q54YW8-F1 Predicted AlphaFoldDB

No variants for Q54YW8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54YW8

No associated diseases with Q54YW8

4 regional properties for Q54YW8

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 6 - 238 IPR003439
domain AAA+ ATPase domain 32 - 215 IPR003593
domain Transport-associated OB, type 2 276 - 344 IPR013611
conserved_site ABC transporter-like, conserved site 138 - 152 IPR017871

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
RNA polymerase I complex RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
RNA polymerase II, core complex RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
RNA polymerase III complex RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.

3 GO annotations of biological process

Name Definition
transcription by RNA polymerase I The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
transcription by RNA polymerase III The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSILFEDTF EVKEIDPDGK KFDRVSRFVC YSENYEMDLQ IDIATHIYPL GHERFKMVLA
70 80 90 100 110 120
SSLNLDGSSD NSGSYDTNKP SLADKYDYVM YGKIFKYQKE NSSSKVSVFA SFGGLLVLLQ
130 140
GDPRYLPGIE LDARIYLLIK KA