Q54YA7

PR
Gene name
tsr1 (DDB_G0278331)
Protein name
Pre-rRNA-processing protein TSR1 homolog
Names
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0278331
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-107 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54YA7

Entry ID Method Resolution Chain Position Source
AF-Q54YA7-F1 Predicted AlphaFoldDB

No variants for Q54YA7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54YA7

No associated diseases with Q54YA7

1 regional properties for Q54YA7

Type Name Position InterPro Accession
domain tRNA(Ile)-lysidine/2-thiocytidine synthase, N-terminal 44 - 206 IPR011063

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
U3 snoRNA binding Binding to a U3 small nucleolar RNA.

2 GO annotations of biological process

Name Definition
endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae.
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEHRHRSGD LHQQNKGFKG GKHDSKGAIK RRAQGKIETN GARQSIKNLA IVNNKDAMRQ
70 80 90 100 110 120
KHQKLVKSKK NELLERKRLG LPDQVAPRVV TIIKLSESCN TKKVKEMLLQ KFKLNINTGE
130 140 150 160 170 180
MEMDNEETLN NKNNNNDNFT TISLTSKVRM MLLECQTMAY DQVIEFCKLS DIILFVIDAN
190 200 210 220 230 240
QAKLNSEAER IFTIVKAQSV PTVIEIIQNL DQTPIKKRNE LKKSIQSVFH FHFPNEPKVL
250 260 270 280 290 300
PMDTNDECSQ VLRYIENIHV NEIIWRKVRP YMLIEKSSYI PETKVVTIDG FIRGNNLSAK
310 320 330 340 350 360
QIIHIPDYGD FQIEKIELID DPHIRKKSYY TNNNNNNSNN NNTGGGEMEQ DKKINILDKV
370 380 390 400 410 420
DQKDKDTLQT WNVPDPMDNE QALPTAEEMK EIEANKKKKL VPKGTSGYQS SWYLDNESDE
430 440 450 460 470 480
EEENFENEDL DMNQEEMGQD KEEEMGEEEE MGEEEEEEEE GQEELEEVKE SNKWKGIKHK
490 500 510 520 530 540
SQITDELLKD SDDEDDDENK EEQSEDEDED ERKQLQQDEI LYPDEVDTPG NVPSRIRFSK
550 560 570 580 590 600
FRGLKSFRSS PWDVKENLPI DYAKIFQFHS FNQSMRASIA ILDNAPAKPD MYVRIHLVNG
610 620 630 640 650 660
PKQLVERNTT AITTKPEVAV GLYRYENKIS LLHFSVEKHK SYEETVRSKE EVYFHFGWRK
670 680 690 700 710 720
FSTSPIYSIS SPNCDKQKFE KFLLPARNTM ATIYGPITYP PAPLLIFNGK DCNELVATGY
730 740 750 760 770 780
LSSVNPDRII CKRIILTGVI AKSISKKFVT VKDMFYYPED INWFKKVELY TKMGRVGHIK
790 800 810 820
EPLGTHGRMK CQFDGTMNQQ DTVCMNLYKR VYPKWIKDDS SLLKLE