Q54XL6
Gene name |
fray1 |
Protein name |
Serine/threonine-protein kinase fray1 |
Names |
STE20-like kinase fray1 |
Species |
Dictyostelium discoideum (Slime mold) |
KEGG Pathway |
ddi:DDB_G0278863 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
238-262 (Activation loop from InterPro)
Target domain |
97-357 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q54XL6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q54XL6-F1 | Predicted | AlphaFoldDB |
No variants for Q54XL6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q54XL6 | |||||
No associated diseases with Q54XL6
1 regional properties for Q54XL6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 97 - 357 | IPR000719 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| serine/threonine protein kinase complex | A protein complex which is capable of protein serine/threonine kinase activity. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activator activity | Binds to and increases the activity of a protein serine/threonine kinase. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of protein kinase activity | Any process that initiates the activity of an inactive protein kinase. |
| protein export from nucleus | The directed movement of a protein from the nucleus into the cytoplasm. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEINNSNNNN | NYVCAQHNRI | EHANHHDLPD | SDSDSSSREE | ELMNSSGGGN | GKEPIGEKKK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LPSHISEVIS | NERRESIIRE | LQQIKTISDY | PSQANQYNLI | EPIGEGTEGR | VFKAYCIPLK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ENVAIKVVEL | DKMDPQFVKD | VIKEVKVMNG | NNHPNLIHYH | TSFLENNQLW | LVMDYLGGGS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LADIMKFKYP | DGIPEVLAVT | VLKSLLKGLE | YLHSHQRIHR | DLKSDNILIG | EDGAIELADF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GVSAMFEKNT | CCSRKTIVGT | PCWMAPEIIS | ERGYNQGVDI | WSFGITAIEL | IRGKPPGYDL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PPSKVFMNLL | FGNSPSLQEE | EDKGVCSHLY | KDLVDKCLQK | EPSKRPNASK | LLEHKVFKQA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KKNNYIVSHL | LHGLTPCEDR | YRESMSPASS | NTPSPDSSRP | SSPEHYNHGN | VVNSPLQKNI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KPSSLNKSSS | SLELKNKNLS | NPDLVNMPRA | ASHPVELNAL | ELSSGSGPLS | QSSDLPHGHL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HKIGTPKKKH | SPSGSIGDSH | GSISPPLSTS | PEKERKKGFF | NHFRRHSIAK | LFGSPKEGDH |
| 550 | 560 | 570 | |||
| NHQHHKSEGD | HEHHHFHFPW | KHHHHSSSNN | HVET |