Q54VN2

PR
Gene name
coq5
Protein name
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Names
Ubiquinone biosynthesis methyltransferase COQ5
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0280237
EC number
2.1.1.201: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54VN2

Entry ID Method Resolution Chain Position Source
AF-Q54VN2-F1 Predicted AlphaFoldDB

No variants for Q54VN2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54VN2

No associated diseases with Q54VN2

2 regional properties for Q54VN2

Type Name Position InterPro Accession
conserved_site UbiE/COQ5 methyltransferase, conserved site 71 - 86 IPR023576-1
conserved_site UbiE/COQ5 methyltransferase, conserved site 221 - 235 IPR023576-2

Functions

Description
EC Number 2.1.1.201 Methyltransferases
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extrinsic component of mitochondrial inner membrane The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.
2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.
methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.

4 GO annotations of biological process

Name Definition
aerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
methylation The process in which a methyl group is covalently attached to a molecule.
ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
ubiquinone metabolic process The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLQSLNRSVR YLSTSIGSRL YCSNTNQTTK NNTNASGVND NQQTHFGFKT VNKEDKESMV
70 80 90 100 110 120
KDVFDSVSSS YDLMNDVMSM GIHRLWKDEL INTLNPTPGS HLLDVAGGTG DISFRFLDKI
130 140 150 160 170 180
KTSPNYFPNI NKSNNGGGEV LKSSSLPSSA TVFDINQSML NEGKKRGLNK GYTDQSDPSI
190 200 210 220 230 240
DWVQGNSEQL PFKDNTFNCY TVSFGIRNCT NIDQVLREAY RVLKPGGRFL CLEFSQVPNP
250 260 270 280 290 300
LLRFAYDQYS FNVIPIMGQL ISGDRDSYSY LVESIRKFPD QETFVQMIQD AGFKQVTYKN
310
LTFGICSIHS GFKL