Q54U31

PR
Gene name
shkD (DDB_G0281343)
Protein name
Dual specificity protein kinase shkD
Names
SH2 domain-containing protein 4, SH2 domain-containing protein D
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0281343
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-303 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

417-425 (Activation loop from InterPro)

Target domain

277-534 (Protein kinase domain)

Relief mechanism

Assay

436-440 (Activation loop from InterPro)

Target domain

277-534 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q54U31

Entry ID Method Resolution Chain Position Source
AF-Q54U31-F1 Predicted AlphaFoldDB

No variants for Q54U31

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54U31

No associated diseases with Q54U31

6 regional properties for Q54U31

Type Name Position InterPro Accession
domain Protein kinase domain 277 - 534 IPR000719
domain SH2 domain 639 - 725 IPR000980
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 281 - 528 IPR001245
active_site Serine/threonine-protein kinase, active site 396 - 408 IPR008271
binding_site Protein kinase, ATP binding site 283 - 308 IPR017441
domain ShkD/ShkE, SH2 domain 630 - 713 IPR035845

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKRFFSNLFK RKQDQNSHIK QINGPTTSTP TTTPTTPTTP TTTQTPTPQN NNTNNNTNNN
70 80 90 100 110 120
NNTNSNNSNQ QKKEQAQASP STNQTQTPSN NTISTSPTVT TQPSFTPGVI STSKLTTSPP
130 140 150 160 170 180
ESPRPPTSTT NTTQPSTTTT TATNSTNTNT ASAPTKTASP SSPSATASPN NNSNNTTTTA
190 200 210 220 230 240
ATTTTTTTTT TTTNANQTAS VNHTSSDQSL NAQNVTQTNN NNNNNNNNNN NNNANNTKPI
250 260 270 280 290 300
NPNDYIPLDF VDSTPKVDNN QPKRKASGPP EILPEEIDRT DFLGQGSFGS VYKGKCRGQE
310 320 330 340 350 360
VAVKIPRKQK LSLYELTSFR HEVKIMSKIF HPNVVLFLGA CTQSGKMQIV TELCQTDLEK
370 380 390 400 410 420
LLHNDRTKKE FSLFRRMQMA KDAALGMNWL HGITRIVHND LKTANLLVDI NLRVKVTDFG
430 440 450 460 470 480
FSQIKEGEEF QDKAAKGTPL WMAPEVMMGN PYNEKADVYS FGIILWEILT KEAPYSHHKD
490 500 510 520 530 540
YDIFFNAICN EKERPPIPAD TLPSLRHLIQ TCWDHNPQNR PSFSEILFRL NEILIDCAID
550 560 570 580 590 600
FDDGRKYWKE HFLVPKQELQ EEVEWSDFEK TLKATHKQLN LDYAPLKELL VQQSHQTVQK
610 620 630 640 650 660
TKQVVTMERF DKVSKWFGSF FEPNTGIETI DNINKLSAKI WFHGDIVREQ ATSRLSKAAE
670 680 690 700 710 720
GAFLIRLSST EPKTCPFTLS MKNNQHRRIQ LIDENNFTGF KIQGKTAVYN SLIELVEKCN
730 740
DYPLLVPCPK FTQETFNPYD PYTN