Q54TF8

PR
Gene name
helC (ddx19, DDB_G0281553)
Protein name
ATP-dependent RNA helicase ddx19
Names
ATP-dependent RNA helicase helC, DEAD box protein 19
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0281553
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-88 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q54TF8

Entry ID Method Resolution Chain Position Source
AF-Q54TF8-F1 Predicted AlphaFoldDB

No variants for Q54TF8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54TF8

No associated diseases with Q54TF8

1 regional properties for Q54TF8

Type Name Position InterPro Accession
active_site Delta-aminolevulinic acid dehydratase, active site 241 - 253 IPR030656

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
poly(A)+ mRNA export from nucleus The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
sorocarp development The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEKETNTTS TENKEKEKQE QTNTNSTTES TNNQVDEEYE RPGRSEGLDE FGIQLDIQQS
70 80 90 100 110 120
DPNSPLYSVK TFEELGLKPE LLKGVYAMGY NKPSKIQEAA LPIIIQSPNN LIAQSQSGTG
130 140 150 160 170 180
KTAAFTLGML NCVDPSINAP QAICISPTKE LALQTFEVIS KIGQFSNIKP LLYISEIEVP
190 200 210 220 230 240
KNVTNQVIIG TPGKILENVI KKQLSVKFLK MVVLDEADFI VKMKNVPNQI AMINRLLPSN
250 260 270 280 290 300
VKVCLFSATF SMGVEELIKK IVQDPYTSIR LKRQELSVEK IHQYFIDCGS EDNKALILSD
310 320 330 340 350 360
IYGFISVGQS IVFVHTIATA KSVHQKMVDE GHSVSLLYGK DLTTEERFKQ IKDFKDGKSK
370 380 390 400 410 420
VLITTNVLAR GIDIPQVSLV INYDVPLDEM GKPDPVHYLH RIGRVGRFGR SGVALSFVYD
430 440 450 460
QQSTNKLMNI STHLGVPLKE LKSSEIESLD GILKGIRNQL TPLNN