Q54RB2
Gene name |
cdk11 (DDB_G0283279) |
Protein name |
Cyclin-dependent kinase 11 |
Names |
Cell division cycle protein kinase 11, Cell division protein kinase 11, PITSVRE serine/threonine protein-kinase cdk11 |
Species |
Dictyostelium discoideum (Slime mold) |
KEGG Pathway |
ddi:DDB_G0283279 |
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
193-216 (Activation loop from InterPro)
Target domain |
52-336 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q54RB2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q54RB2-F1 | Predicted | AlphaFoldDB |
No variants for Q54RB2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q54RB2 | |||||
No associated diseases with Q54RB2
2 regional properties for Q54RB2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ResB-like domain | 30 - 295 | IPR007816-1 |
| domain | ResB-like domain | 318 - 447 | IPR007816-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of mitotic cell cycle | Any process that modulates the rate or extent of progress through the mitotic cell cycle. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNIQENENK | ETCNIKENEN | KEILKENFKN | KEKQYFSSLR | SPYSACRSVD | CFKKLYTINE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GAFGVVYCAQ | DKETEEIVAL | KKIKMERERE | GIPITSVREI | KVLMELKHDN | IVQIKEIVLG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KNINSIFMAM | EFIDHDLRGL | MEVIKKPFLP | SEIKTLIQQL | LNGVSYMHDN | WVIHRDLKTA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NLLYTNKGVL | KIADFGLARE | YGSPLKPLSK | GVVTLWYRAP | ELLLDTEIYT | PAIDIWSVGC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IFAEIISKEV | LLQGSSEIDQ | MDKIFKLFGT | PTEKSWPAFF | KLPLAKYFNL | TDQPYNNLKS |
| 310 | 320 | 330 | 340 | 350 | |
| KFPHITDNAF | DLLNKLLELN | PEARISASDA | LKHPYFFENP | QPRDPLLMPT | WPSSHKKT |