Q54R82

PR
Gene name
mkkA
Protein name
Mitogen-activated protein kinase kinase kinase A
Names
MAPK/ERK kinase 1, MEK kinase 1, MEKK 1, MAPK/ERK kinase A, MEK kinase A, MEKK A, MEKKalpha
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0283265
EC number
2.7.11.25: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

64-171 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

314-337 (Activation loop from InterPro)

Target domain

170-429 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q54R82

Entry ID Method Resolution Chain Position Source
AF-Q54R82-F1 Predicted AlphaFoldDB

No variants for Q54R82

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54R82

No associated diseases with Q54R82

16 regional properties for Q54R82

Type Name Position InterPro Accession
domain PB1 domain 15 - 101 IPR000270
domain Protein kinase domain 170 - 429 IPR000719
repeat WD40 repeat 598 - 639 IPR001680-1
repeat WD40 repeat 681 - 724 IPR001680-2
repeat WD40 repeat 727 - 900 IPR001680-3
repeat WD40 repeat 903 - 942 IPR001680-4
domain F-box domain 524 - 565 IPR001810
active_site Serine/threonine-protein kinase, active site 293 - 305 IPR008271
binding_site Protein kinase, ATP binding site 176 - 199 IPR017441
conserved_site WD40 repeat, conserved site 624 - 638 IPR019775-1
conserved_site WD40 repeat, conserved site 754 - 768 IPR019775-2
conserved_site WD40 repeat, conserved site 803 - 817 IPR019775-3
conserved_site WD40 repeat, conserved site 843 - 857 IPR019775-4
repeat G-protein beta WD-40 repeat 624 - 638 IPR020472-1
repeat G-protein beta WD-40 repeat 843 - 857 IPR020472-2
repeat G-protein beta WD-40 repeat 927 - 941 IPR020472-3

Functions

Description
EC Number 2.7.11.25 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane ; Single-pass membrane protein
  • Localized predominantly at the periphery of the cells, possibly in the cortex or the plasma membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
anatomical structure morphogenesis The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
protein phosphorylation The process of introducing a phosphate group on to a protein.
sorocarp development The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
sporulation resulting in formation of a cellular spore The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSWLNNPSQN FVDPFIRIKC ILGDDIRIIK FNSNISYGGL MNQLEQDFQC PISIHQYEDY
70 80 90 100 110 120
EGDKVTVKSK DDIMEALTMY FELKALNPTK IISTKFFLKQ LPPQSQPLSS SLSPTQSLIL
130 140 150 160 170 180
NNNNNNNNNN NNNNNNNNNN NNNNIIQHTD FPSLIINEHE ELISNHNIKW QKGQILGRGG
190 200 210 220 230 240
YGSVYLGLNK DTGELFAVKQ LEIVDINSDP KLKNMILSFS KEIEVMRSLR HDNIVRYLGT
250 260 270 280 290 300
SLDQSFLSVF LEYIPGGSIS SLLGKFGAFS ENVIKVYTKQ ILQGLSFLHA NSIIHRDIKG
310 320 330 340 350 360
ANILIDTKGI VKLSDFGCSK SFSGIVSQFK SMQGTPYWMA PEVIKQTGHG RSSDIWSLGC
370 380 390 400 410 420
VIVEMATAQP PWSNITELAA VMYHIASSNS IPNIPSHMSQ EAFDFLNLCF KRDPKERPDA
430 440 450 460 470 480
NQLLKHPFIM NLDDNIQLPT ISPTTTLSTN TTNTTATTTT TNNATNSNIN QQQQQQQQQP
490 500 510 520 530 540
PTRTQRVSIS AGSSNNKRYT PPISTSTSSS SSSILNNFSI NIILPINLII LIFREIKPNF
550 560 570 580 590 600
VNTLSRVCKH WKQIIDDDEL WNKYCSDRLI NKSKFEESIT WKSNYIKIYK QQKVWFHNKL
610 620 630 640 650 660
NHSTLKGHDK GVFCVKLIDD QGMVLSGGED KKLKVWDISG NHHHNHHSGI VGSISKKSGL
670 680 690 700 710 720
NIINNNNSNN SNSSSNSSSS NSRYLFSLKG HSGCIKSVDY QRQSGSDVSR VFTASADFTC
730 740 750 760 770 780
KIFSLKTKKT LFTYTNHQEA VTCINYLGDV ENKCITSSLD KTIQLWDAET GSCLSTLRGH
790 800 810 820 830 840
TGGIYCVKTD QVATHGNGYN HLVVSASVDK TSNVWDTRSS SKVRSFTQHT EDVLCCYVFD
850 860 870 880 890 900
QKVVTGSCDG TIKLWDIGTG KTISTFIPSE TRQKNYVWTV QFDQSKIISS GKTGIIRIWD
910 920 930 940
IYNERDSRSI GGHHETIFSL QFNNQKLITG SLDKLVKIWS ID